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Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation.

Authors: TiruthaniKarthik，MischlerAdam，AhmedShoeb，MahinthakumarJessica，HaughJason M，RaoBala

Journal: Sci Signal

PubMed ID: 31164479

Doi: 10.1126/scisignal.aap7584

Products & Services: Peptide Synthesis

A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.

Authors: SoChun，SeresK Bianka，SteyerAnna M，M?nnichEike，CliftDean，PejkovskaAnastasija，M?biusWiebke，SchuhMe

Journal: Science

PubMed ID: 31249032

Doi: 10.1126/science.aat9557

Products & Services: Peptide Synthesis

Tau local structure shields an?amyloid-forming motif and controls aggregation propensity.

Authors: ChenDailu，DromboskyKenneth W，HouZhiqiang，SariLevent，KashmerOmar M，RyderBryan D，PerezValerie A，WoodardDaNae R，LinMilo M，DiamondMarc I，JoachimiakLuka

Journal: Nat Commun

PubMed ID: 31175300

Doi: 10.1038/s41467-019-10355-1

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The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif.

Authors: ChenMo，ChoiSuyong，JungOisun，WenTianmu，BaumChristina，ThapaNarendra，LambertPaul F，RapraegerAlan C，AndersonRicha

Journal: Sci Rep

PubMed ID: 31235839

Doi: 10.1038/s41598-019-45671-5

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Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.

Authors: ShenKoning，GamerdingerMartin，ChanRebecca，GenseKarina，MartinEsther M，SachsNadine，KnightPatrick D，SchlömerRenate，CalabreseAntonio N，StewartKatie L，LeiendeckerLukas，BaghelAnkit，RadfordSheena E，FrydmanJudith，Deuerling

Journal: Mol. Cell

PubMed ID: 30982745

Doi: 10.1016/j.molcel.2019.03.012

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Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin.

Authors: YeLiang，SchnepfDaniel，BeckerJan，EbertKarolina，TanriverYakup，BernasconiValentina，GadHans Henrik，HartmannRune，LyckeNils，StaeheliP

Journal: Nat. Immunol.

PubMed ID: 30886417

Doi: 10.1038/s41590-019-0345-x

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CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells.

Authors: GaetePablo S，LilloMauricio A，PueblaMariela，PobleteInés，FigueroaXavi

Journal: Sci Rep

PubMed ID: 31138827

Doi: 10.1038/s41598-019-44333-w

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Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer's disease.

Authors: TaoChih-Chieh，ChengKuang-Min，MaYun-Li，HsuWei-Lun，ChenYan-Chu，FuhJong-Ling，LeeWei-Ju，ChaoChih-Chang，LeeEminy

Journal: Cell Death Differ

PubMed ID: 31127200

Doi: 10.1038/s41418-019-0348-z

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Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance.

Authors: LancasterJ N，ThyagarajanH M，SrinivasanJ，LiY，HuZ，EhrlichL

Journal: Nat Commun

PubMed ID: 31101805

Doi: 10.1038/s41467-019-09727-4

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Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy.

Authors: Perez-RuizElisabeth，MinuteLuna，OtanoItziar，AlvarezMaite，OchoaMaria Carmen，BelsueVirginia，de AndreaCarlos，Rodriguez-RuizMaria Esperanza，Perez-GraciaJose Luis，Marquez-RodasIvan，LlacerCasilda，AlvarezMartina，de LuqueVanesa，MolinaCarmen，TeijeiraAlvaro，BerraondoPedro，MeleroIgn

Journal: Nature

PubMed ID: 31043740

Doi: 10.1038/s41586-019-1162-y

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