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Phrixotoxin-3 binds to three distinct antagonistic sites on human Nav1.6

Authors: Xiao Fan, Jiaofeng Chen, Xiaoshuang Huang, Zhanfeng Hou, Yuzhen Xie, Zigang Li, Nieng Yan, Jian Huang

Journal: Cell Research

PubMed ID: 40615637

Doi: 10.1038/s41422-025-01141-4

Products & Services: Peptide Synthesis

Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules

Authors: Arunraj Dhamodaran, Xiaojing Chen, Niklas Fellmer, Deepti Agrawal, Eric Danner, Ralf Kühn, Thomas Blankenstein

Journal: Nature Communications

PubMed ID: 40593800

Doi: 10.1038/s41467-025-61306-y

Products & Services: Peptide Synthesis

Extracellular CIRP dysregulates microglial efferocytosis in ischemic stroke via the TLR4/miR-155/MafB axis

Authors: Dmitriy Lapin; Dilara Aylar; Archna Sharma; Ping Wang

Journal: research square

PubMed ID: 40766256

Doi: 10.21203/rs.3.rs-7223452/v1

Products & Services: Peptide Synthesis

Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

Authors: Hui Yuan 1, Pengcheng Xiao 2, Wei Huang 2, Wenguo Cui 1

Journal: Advanced Science

PubMed ID: 40667608

Doi: 10.1002/advs.202504319

Products & Services: Peptide Synthesis

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

Authors: Dapeng Li; Yuanfan Li; Jie Cang; Xianwen Yan; Feipeng Wu; Xuan Sun; Wenchao Zhang

Journal: Frontiers in pharmacology

PubMed ID: 40264674

Doi: 10.3389/fphar.2025.1584245

Products & Services: Peptide Synthesis

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria

Authors: Belen Sotomayor, Thomas C Donahue, Sai Pooja Mahajan, May N Taw, Sophia W Hulbert, Erik J Bidstrup, D Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A Alabi, Parastoo Azadi, Jeffrey J Gray, Michael C Jewett, Lai-Xi Wang, Matthew P DeLisa

Journal: Nature Communications

PubMed ID: 40610439

Doi: 10.1038/s41467-025-61440-7

Products & Services: Peptide Synthesis

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Authors: Markella Konstantinidou, Marios Zingiridis, Marloes A M Pennings, Michael Fragkiadakis, Johanna M Virta, Jezrael L Revalde, Emira J Visser, Christian Ottmann, Luc Brunsveld, Constantinos G Neochoritis, Michelle R Arkin

Journal: Nature Communications

PubMed ID: 40659654

Doi: 10.1038/s41467-025-61176-4

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Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation

Authors: Jeremy M. Lowen, Erika E. Wheeler, Nathan K. Shimamoto, David H. Ramos-Rodriguez, Katherine H. Griffin, Gabriella C. Bond, J. Kent Leach

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202311017

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Circulating myeloid-derived suppressor cell load and disease severity are associated to an enhanced oligodendroglial production in a murine model of multiple sclerosis

Authors: Mari Paz Serrano-Regal, Celia Camacho-Toledano, Inmaculada Alonso-García, María Cristina Ortega, Isabel Machín-Díaz, Rafael Lebrón-Galán, Jénnifer García-Arocha, Leticia Calahorra, Manuel Nieto-Díaz, Diego Clemente

Journal: Neurobiology of Disease

PubMed ID: 40250717

Doi: 10.1016/j.nbd.2025.106919

Products & Services: Peptide Synthesis

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng

Journal: Advanced Science

Doi: doi.org/10.1002/advs.202416809

Products & Services: Peptide Synthesis