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A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

Authors: David J DiLillo, Kara Olson, Katja Mohrs, Thomas Craig Meagher, Kevin Bray, Olga Sineshchekova, Thomas Startz, Jessica Kuhnert, Marc W Retter, Stephen Godin, Prachi Sharma, Frank Delfino, John Lin, Eric Smith, Gavin Thurston, Jessica R Kirshner

Journal: Blood Adv

PubMed ID: 33651100

Doi: 10.1182/bloodadvances.2020002736

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Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII4 noroviruses

Authors: Joseph A Kendra, Kentaro Tohma, Lauren A Ford-Siltz, Cara J Lepore, Gabriel I Parra

Journal: Proc Natl Acad Sci U S A

PubMed ID: 33836574

Doi: 10.1073/pnas.2015874118

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The Overexpression of Suppresses the Ovarian Cancer Progression the Inhibition of Integrin β1/AKT Signaling Pathway

Authors: Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao

Journal: Front Oncol

PubMed ID: 33869039

Doi: 10.3389/fonc.2021.644840

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Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

Authors: Xiaomin Ni, Martin Schröder, Vincent Olieric, May E Sharpe, Victor Hernandez-Olmos, Ewgenij Proschak, Daniel Merk, Stefan Knapp, Apirat Chaikuad

Journal: ACS Med Chem Lett

PubMed ID: 33850605

Doi: 10.1021/acsmedchemlett.0c00684

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Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs

Authors: Katherine M Almasy, Jonathan P Davies, Lars Plate

Journal: biorxiv

PubMed ID: 33758849

Doi: 10.1101/2021.03.08.434440

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LncRNA OTUD6B-AS1 inhibits many cellular processes in colorectal cancer by sponging miR-21-5p and regulating PNRC2

Authors: Y Cai, Y Li, C Shi, Z Zhang, J Xu, B Sun

Journal: Hum Exp Toxicol

PubMed ID: 33686892

Doi: 10.1177/0960327121997976

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Design of buried charged networks in artificial proteins

Authors: Mona Baumgart, Michael Röpke, Max E Mühlbauer, Sam Asami, Sophie L Mader, Kai Fredriksson, Michael Groll, Ana P Gamiz-Hernandez, Ville R I Kaila

Journal: Nat Commun

PubMed ID: 33767131

Doi: 10.1038/s41467-021-21909-7

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A single-dose, implant-based, trivalent virus-like particle vaccine against "cholesterol checkpoint" proteins

Authors: Oscar A Ortega-Rivera, Jonathan K Pokorski, Nicole F Steinmetz

Journal: Adv Ther (Weinh)

PubMed ID: 34541299

Doi: 10.1002/adtp.202100014

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Crystal structure of P falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding

Authors: Brian Nguyen, Rui Ma, Wai Kwan Tang, Dashuang Shi, Niraj H Tolia

Journal: Sci Rep

PubMed ID: 33723304

Doi: 10.1038/s41598-021-85197-3

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Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

Authors: Lingdi Zhang, Timothy A Vickers, Hong Sun, Xue-Hai Liang, Stanley T Crooke

Journal: Nucleic Acids Res

PubMed ID: 33577678

Doi: 10.1093/nar/gkab078

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