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The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway

Authors: Qiqi Cao, Chun Zhao, Congjing Wang, Lingbo Cai, Meng Xia, Xiaolan Zhang, Jian Han, Yangyang Xu, Junqiang Zhang, Xiufeng Ling, Xiang Ma, Ran Huo

Journal: Front Cell Dev Biol

PubMed ID: 33614659

Doi: 10.3389/fcell.2021.628649

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Self-assembly and regulation of protein cages from pre-organised coiled-coil modules

Authors: Fabio Lapenta, Jana Aupič, Marco Vezzoli, Žiga Strmšek, Stefano Da Vela, Dmitri I Svergun, José María Carazo, Roberto Melero, Roman Jerala

Journal: Nat Commun

PubMed ID: 33574245

Doi: 10.1038/s41467-021-21184-6

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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Authors: Chris A Brosey, Jerry H Houl, Panagiotis Katsonis, Lakshitha P F Balapiti-Modarage, Shobanbabu Bommagani, Andy Arvai, Davide Moiani, Albino Bacolla, Todd Link, Leslie S Warden, Olivier Lichtarge, Darin E Jones, Zamal Ahmed, John A Tainer

Journal: Prog Biophys Mol Biol

PubMed ID: 33636189

Doi: 10.1016/j.pbiomolbio.2021.02.002

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A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light

Authors: Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, Daisuke Shibata, Misa Shibata, Kogiku Shiba, Masaki Kita, Hideo Kigoshi, Yui Tanaka, Yuya Yamasaki, Yuma Asahina, Chihong Song, Mami Nomura, Mamoru Nomura, Ayako Nakajima, Mia Nakachi, Lixy Yamada, Shiori Nakazawa, Hitoshi Sawada, Kazuyoshi Murata, Kaoru Mitsuoka, Takashi Ishikawa, Ken-Ichi Wakabayashi, Takahide Kon, Kazuo Inaba

Journal: Sci Adv

PubMed ID: 33637535

Doi: 10.1126/sciadv.abf3621

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Circ_ 0115744 acts as miR-144 sponge to promote and predict the metastasis of colorectal cancer

Authors: Xiaoming Ma, Long Lv, Chungen Xing

Journal: Aging (Albany NY)

PubMed ID: 33591945

Doi: 10.18632/aging.202513

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Functional and conformational impact of cancer-associated mutations depends on the position and the charge of amino acid substitution

Authors: Christine Canbezdi, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Tatiana Popova, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi

Journal: Comput Struct Biotechnol J

PubMed ID: 33777335

Doi: 10.1016/j.csbj.2021.02.012

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Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor

Authors: Joey Sheff, Ping Wang, Ping Xu, Melanie Arbour, Luke Masson, Henk van Faassen, Greg Hussack, Kristin Kemmerich, Eric Brunette, Danica Stanimirovic, Jennifer J Hill, John Kelly, Feng Ni

Journal: Sci Rep

PubMed ID: 33608571

Doi: 10.1038/s41598-021-83198-w

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A fusion transcription factor-driven cancer progresses to a fusion-independent relapse via constitutive activation of a downstream transcriptional target

Authors: Salah Boudjadi, Puspa Raj Pandey, Bishwanath Chatterjee, Thanh Hung Nguyen, Wenyue Sun, Frederic G Barr

Journal: Cancer Res

PubMed ID: 33589519

Doi: 10.1158/0008-5472.CAN-20-1613

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The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

Authors: Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel, Wei Zhuo, Suma Somasekharan, Kasturi Roy, Laixing Zhang, Yang Liu, Xianbin Meng, Haiteng Deng, Wenwen Zeng, Guohui Li, Biff Forbush, Maojun Yang

Journal: Commun Biol

PubMed ID: 33597714

Doi: 10.1038/s42003-021-01750-w

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The kinetic landscape of an RNA-binding protein in cells

Authors: Deepak Sharma, Leah L Zagore, Matthew M Brister, Xuan Ye, Carlos E Crespo-Hernández, Donny D Licatalosi, Eckhard Jankowsky

Journal: Nature

PubMed ID: 33568810

Doi: 10.1038/s41586-021-03222-x

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