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PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity
Authors: Shuang Qu, Zichen Jiao, Geng Lu, Bing Yao, Ting Wang, Weiwei Rong, Jiahan Xu, Ting Fan, Xinlei Sun, Rong Yang, Jun Wang, Yongzhong Yao, Guifang Xu, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen
Journal: Genome Biol
PubMed ID: 33849634
Doi: 10.1186/s13059-021-02331-0
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Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
Authors: Simon Bo Jensen, Sara Thodberg, Shaheena Parween, Matias E Moses, Cecilie C Hansen, Johannes Thomsen, Magnus B Sletfjerding, Camilla Knudsen, Rita Del Giudice, Philip M Lund, Patricia R Castaño, Yanet G Bustamante, Maria Natalia Rojas Velazquez, Flemming Steen Jørgensen, Amit V Pandey, Tomas Laursen, Birger Lindberg Møller, Nikos S Hatzakis
Journal: Nat Commun
PubMed ID: 33859207
Doi: 10.1038/s41467-021-22562-w
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HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia
Authors: Juanyu Gao, Wenjing Feng, Wei Lv, Wenhui Liu, Caihua Fu
Journal: Int Heart J
PubMed ID: 33678793
Doi: 10.1536/ihj.20-315
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The Overexpression of Suppresses the Ovarian Cancer Progression the Inhibition of Integrin β1/AKT Signaling Pathway
Authors: Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao
Journal: Front Oncol
PubMed ID: 33869039
Doi: 10.3389/fonc.2021.644840
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A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells
Authors: David J DiLillo, Kara Olson, Katja Mohrs, Thomas Craig Meagher, Kevin Bray, Olga Sineshchekova, Thomas Startz, Jessica Kuhnert, Marc W Retter, Stephen Godin, Prachi Sharma, Frank Delfino, John Lin, Eric Smith, Gavin Thurston, Jessica R Kirshner
Journal: Blood Adv
PubMed ID: 33651100
Doi: 10.1182/bloodadvances.2020002736
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Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII4 noroviruses
Authors: Joseph A Kendra, Kentaro Tohma, Lauren A Ford-Siltz, Cara J Lepore, Gabriel I Parra
Journal: Proc Natl Acad Sci U S A
PubMed ID: 33836574
Doi: 10.1073/pnas.2015874118
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Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain
Authors: Xiaomin Ni, Martin Schröder, Vincent Olieric, May E Sharpe, Victor Hernandez-Olmos, Ewgenij Proschak, Daniel Merk, Stefan Knapp, Apirat Chaikuad
Journal: ACS Med Chem Lett
PubMed ID: 33850605
Doi: 10.1021/acsmedchemlett.0c00684
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Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs
Authors: Katherine M Almasy, Jonathan P Davies, Lars Plate
Journal: biorxiv
PubMed ID: 33758849
Doi: 10.1101/2021.03.08.434440
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LncRNA OTUD6B-AS1 inhibits many cellular processes in colorectal cancer by sponging miR-21-5p and regulating PNRC2
Authors: Y Cai, Y Li, C Shi, Z Zhang, J Xu, B Sun
Journal: Hum Exp Toxicol
PubMed ID: 33686892
Doi: 10.1177/0960327121997976
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Design of buried charged networks in artificial proteins
Authors: Mona Baumgart, Michael Röpke, Max E Mühlbauer, Sam Asami, Sophie L Mader, Kai Fredriksson, Michael Groll, Ana P Gamiz-Hernandez, Ville R I Kaila
Journal: Nat Commun
PubMed ID: 33767131
Doi: 10.1038/s41467-021-21909-7
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