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Assessment of Babesia bovis 6cys A and 6cys B as components of transmission blocking vaccines for babesiosis

Authors: Heba F Alzan, Reginaldo G Bastos, Massaro W Ueti, Jacob M Laughery, Vignesh A Rathinasamy, Brian M Cooke, Carlos E Suarez

Journal: Parasit Vectors

PubMed ID: 33879245

Doi: 10.1186/s13071-021-04712-7

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A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease

Authors: Gerhard Leinenga, Wee Kiat Koh, Jürgen Götz

Journal: Alzheimers Res Ther

PubMed ID: 33836798

Doi: 10.1186/s13195-021-00809-4

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CD27CD38 plasmablasts are activated B cells of mixed origin with distinct function

Authors: Angeline Rouers, Ramapraba Appanna, Marion Chevrier, Josephine Lum, Mai Chan Lau, Lingqiao Tan, Thomas Loy, Alicia Tay, Raman Sethi, Durgalakshmi Sathiakumar, Kaval Kaur, Julia Böhme, Yee-Sin Leo, Laurent Renia, Shanshan W Howland, Amit Singhal, Jinmiao Chen, Katja Fink

Journal: iScience

PubMed ID: 34113823

Doi: 10.1016/j.isci.2021.102482

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PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity

Authors: Shuang Qu, Zichen Jiao, Geng Lu, Bing Yao, Ting Wang, Weiwei Rong, Jiahan Xu, Ting Fan, Xinlei Sun, Rong Yang, Jun Wang, Yongzhong Yao, Guifang Xu, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen

Journal: Genome Biol

PubMed ID: 33849634

Doi: 10.1186/s13059-021-02331-0

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Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

Authors: Simon Bo Jensen, Sara Thodberg, Shaheena Parween, Matias E Moses, Cecilie C Hansen, Johannes Thomsen, Magnus B Sletfjerding, Camilla Knudsen, Rita Del Giudice, Philip M Lund, Patricia R Castaño, Yanet G Bustamante, Maria Natalia Rojas Velazquez, Flemming Steen Jørgensen, Amit V Pandey, Tomas Laursen, Birger Lindberg Møller, Nikos S Hatzakis

Journal: Nat Commun

PubMed ID: 33859207

Doi: 10.1038/s41467-021-22562-w

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HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia

Authors: Juanyu Gao, Wenjing Feng, Wei Lv, Wenhui Liu, Caihua Fu

Journal: Int Heart J

PubMed ID: 33678793

Doi: 10.1536/ihj.20-315

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The Overexpression of Suppresses the Ovarian Cancer Progression the Inhibition of Integrin β1/AKT Signaling Pathway

Authors: Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao

Journal: Front Oncol

PubMed ID: 33869039

Doi: 10.3389/fonc.2021.644840

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A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

Authors: David J DiLillo, Kara Olson, Katja Mohrs, Thomas Craig Meagher, Kevin Bray, Olga Sineshchekova, Thomas Startz, Jessica Kuhnert, Marc W Retter, Stephen Godin, Prachi Sharma, Frank Delfino, John Lin, Eric Smith, Gavin Thurston, Jessica R Kirshner

Journal: Blood Adv

PubMed ID: 33651100

Doi: 10.1182/bloodadvances.2020002736

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Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII4 noroviruses

Authors: Joseph A Kendra, Kentaro Tohma, Lauren A Ford-Siltz, Cara J Lepore, Gabriel I Parra

Journal: Proc Natl Acad Sci U S A

PubMed ID: 33836574

Doi: 10.1073/pnas.2015874118

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Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

Authors: Xiaomin Ni, Martin Schröder, Vincent Olieric, May E Sharpe, Victor Hernandez-Olmos, Ewgenij Proschak, Daniel Merk, Stefan Knapp, Apirat Chaikuad

Journal: ACS Med Chem Lett

PubMed ID: 33850605

Doi: 10.1021/acsmedchemlett.0c00684

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