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Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

Authors: Nitzan Tal, Benjamin R Morehouse, Adi Millman, Avigail Stokar-Avihail, Carmel Avraham, Taya Fedorenko, Erez Yirmiya, Ehud Herbst, Alexander Brandis, Tevie Mehlman, Yaara Oppenheimer-Shaanan, Alexander F A Keszei, Sichen Shao, Gil Amitai, Philip J Kranzusch, Rotem Sorek

Journal: Cell

PubMed ID: 34644530

Doi: 10.1016/j.cell.2021.09.031

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Authors: Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O' Brien, Rebecca O'Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Romel Rosales, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Kris M White, Adolfo García-Sastre, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton

Journal: Nat Commun

PubMed ID: 34663813

Doi: 10.1038/s41467-021-26239-2

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Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma

Authors: Dan Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, Bin Wang

Journal: npj Vaccines

PubMed ID: 34611173

Doi: 10.1038/s41541-021-00382-9

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Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants ()

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S Hayward, Paul D Ling

Journal: Microbiol Spectr

PubMed ID: 34668724

Doi: 10.1128/Spectrum.00983-21

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Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide

Authors: Gian Pietro Pietri, Marta Tontini, Barbara Brogioni, Davide Oldrini, Stefania Robakiewicz, Pedro Henriques, Ilaria Calloni, Vera Abramova, Laura Santini, Suzana Malić, Karmela Miklić, Berislav Lisnic, Sara Bertuzzi, Luca Unione, Evita Balducci, Jérôme de Ruyck, Maria Rosaria Romano, Jesus Jimenez-Barbero, Julie Bouckaert, Stipan Jonjic, Tihana Lenac Rovis, Roberto Adamo

Journal: Front Mol Biosci

PubMed ID: 34722634

Doi: 10.3389/fmolb.2021.745360

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Deiodinase-3 is a thyrostat to regulate podocyte homeostasis

Authors: Shivangi Agarwal, Kwi Hye Koh, Nicholas J Tardi, Chuang Chen, Ranadheer Reddy Dande, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Domenico Salvatore, Beata Samelko, Mehmet M Altintas, Steve Mangos, Antonio Bianco, Jochen Reiser

Journal: EBioMedicine

PubMed ID: 34649077

Doi: 10.1016/j.ebiom.2021.103617

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Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice

Authors: Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi

Journal: PeerJ

PubMed ID: 34721976

Doi: 10.7717/peerj.12285

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A New Light on Potential Therapeutic Targets for Colorectal Cancer Treatment

Authors: Wei-Lun Tsai, Chih-Yang Wang, Yu-Cheng Lee, Wan-Chun Tang, Gangga Anuraga, Hoang Dang Khoa Ta, Yung-Fu Wu, Kuen-Haur Lee

Journal: Biomedicines

PubMed ID: 34680556

Doi: 10.3390/biomedicines9101438

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Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway

Authors: Yong Luo, Xiaobing Yang, Spyridon P Basourakos, Xuemei Zuo, Dechao Wei, Jiahui Zhao, Mingchuan Li, Qiankun Li, Tao Feng, Pengju Guo, Yongguang Jiang

Journal: Front Mol Biosci

PubMed ID: 34746227

Doi: 10.3389/fmolb.2021.652443

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miR-29a-3p promotes migration and invasion in ameloblastoma via Wnt/β-catenin signaling by targeting catenin beta interacting protein 1

Authors: Sai Liu, Dongjuan Liu, Jinwen Liu, Jiayi Liu, Ming Zhong

Journal: Head Neck

PubMed ID: 34636093

Doi: 10.1002/hed.26888

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