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Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Authors: Fanning S W，Hodges-Gallagher L，Myles D C，Sun R，Fowler C E，Plant I N，Green B D，Harmon C L，Greene G L，Kushner
Journal: Nat Commun
PubMed ID: 29915250
Doi: 10.1038/s41467-018-04413-3
Products & Services: Mutagenesis Services   
Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.
Authors: De T, Alarcon C, Hernandez W, Liko I, Cavallari LH, Duarte JD, Perera MA.
Journal: JAMA
PubMed ID: 30357299
Doi: 10.1001/jama.2018.14955
Products & Services: Mutagenesis Services   
A Single Complex Agpat2 Allele in a Patient With Partial Lipodystrophy.
Authors: Broekema MF, Massink MPG, De Ligt J, Stigter ECA, Monajemi H,, De Ridder J, Burgering BMT, van Haaften GW, Kalkhoven E.
Journal: Front Physiol
PubMed ID: 30319454
Doi: 10.3389/fphys.2018.01363
Products & Services: Mutagenesis Services   
Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
Authors: Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ.
Journal: Cell
PubMed ID: 30550789
Doi: 10.1016/j.cell.2018.08.044
Products & Services: Mutagenesis Services   
Phosphorylation by protein kinase A disassembles the caspase-9 core.
Authors: SerranoBanyuhay P，HardyJean
Journal: Cell Death Differ.
PubMed ID: 29352269
Doi: 10.1038/s41418-017-0052-9
Products & Services: Mutagenesis Services   
The gating mechanism in cyclic nucleotide-gated ion channels.
Authors: MazzoliniMonica，ArcangelettiManuel，MarchesiArin，NapolitanoLuisa M R，GrosaDebora，MaitySourav，AnselmiClaudio，TorreVin
Journal: Sci Rep
PubMed ID: 29311674
Doi: 10.1038/s41598-017-18499-0
Products & Services: Mutagenesis Services   
Dominant-negative IKZF1 mutations cause a T， B， and myeloid cell combined immunodeficiency.
Authors: BoutboulDavid，KuehnHye Sun，Van de WyngaertZoé，NiemelaJulie E，CallebautIsabelle，StoddardJennifer，LenoirChristelle，BarlogisVincent，FarnarierCatherine，VelyFrédéric，YoshidaNao，KojimaSeiji，KaneganeHirokazu，HoshinoAkihiro，HauckFabian，LhermitteLudovic，AsnafiVahid，RoehrsPhilip，ChenShaoying，VerbskyJames W，CalvoKatherine R，HusamiAmmar，ZhangKejian，RobertsJoseph，AmrolDavid，SleasemanJohn，HsuAmy P，HollandSteven M，MarshRebecca，FischerAlain，FleisherThomas A，PicardCapucine，LatourSylvain，RosenzweigSerg
Journal: J. Clin. Invest.
PubMed ID: 29889099
Doi: 10.1172/JCI98164
Products & Services: Mutagenesis Services   
Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.
Authors: WuZhihao，WangYan，LimJunghyun，LiuBoxiang，LiYanping，VartakRasika，StankiewiczTrisha，MontgomeryStephen，LuBin
Journal: Cell Metab.
PubMed ID: 29861391
Doi: 10.1016/j.cmet.2018.05.007
Products & Services: Mutagenesis Services   
SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts.
Authors: Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC.
Journal: J Am Soc Nephrol
PubMed ID: 30341149
Doi: 10.1681/ASN.2018060573
Products & Services: Mutagenesis Services   
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor.
Authors: Groenendyk J, Paskevicius T, Urra H,,, Viricel C, Wang K, Barakat K, Hetz C,,,,, Kurgan L, Agellon LB, Michalak M.
Journal: Sci Rep
PubMed ID: 30420769
Doi: 10.1038/s41598-018-34891-w
Products & Services: Mutagenesis Services   

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