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A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Authors: Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB6, Gregory J3, March S6, Liao HX7, Haynes BF7,8,9, Wiehe K7,8, Trama AM7, Saunders KO7,10, Gladden MA7, Monroe A7, Bonsignori M7,8, Kanekiyo M1, Wheatley AK1, McDermott AB1, Farney SK1, Chuang GY1, Zhang B1, Kc N11, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.
Journal: Nat Med
PubMed ID: 29554083
Doi: 10.1038/nm.4512
Products & Services: Mutagenesis Services   Peptide Synthesis   Gene Synthesis   
Cell-free production of a therapeutic protein: Expression, purification, and characterization of recombinant streptokinase using a CHO lysate.
Authors: Tran K, Gurramkonda C, Cooper MA, Pilli M, Taris JE, Selock N, Han TC, Tolosa M, Zuber A, Peñalber-Johnstone C, Dinkins C, Pezeshk N, Kostov Y, Frey DD, Tolosa L, Wood DW, Rao G.
Journal: Biotechnol Bioeng.
PubMed ID: 28843001
Products & Services: Mutagenesis Services   
Formate rescues neural tube defects caused by mutations in .
Authors: KimJimi，LeiYunping，GuoJin，KimSung-Eun，WlodarczykBogdan J，CabreraRobert M，LinYing Linda，NilssonTorbjorn K，ZhangTing，RenAiguo，WangLinlin，YuanZhengwei，ZhengYu-Fang，WangHong-Yan，FinnellRicha
Journal: Proc. Natl. Acad. Sci. U.S.A.
PubMed ID: 29666258
Doi: 10.1073/pnas.1800138115
Products & Services: Mutagenesis Services   
Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Authors: Fanning S W，Hodges-Gallagher L，Myles D C，Sun R，Fowler C E，Plant I N，Green B D，Harmon C L，Greene G L，Kushner
Journal: Nat Commun
PubMed ID: 29915250
Doi: 10.1038/s41467-018-04413-3
Products & Services: Mutagenesis Services   
Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.
Authors: De T, Alarcon C, Hernandez W, Liko I, Cavallari LH, Duarte JD, Perera MA.
Journal: JAMA
PubMed ID: 30357299
Doi: 10.1001/jama.2018.14955
Products & Services: Mutagenesis Services   
A Single Complex Agpat2 Allele in a Patient With Partial Lipodystrophy.
Authors: Broekema MF, Massink MPG, De Ligt J, Stigter ECA, Monajemi H,, De Ridder J, Burgering BMT, van Haaften GW, Kalkhoven E.
Journal: Front Physiol
PubMed ID: 30319454
Doi: 10.3389/fphys.2018.01363
Products & Services: Mutagenesis Services   
Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
Authors: Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ.
Journal: Cell
PubMed ID: 30550789
Doi: 10.1016/j.cell.2018.08.044
Products & Services: Mutagenesis Services   
Phosphorylation by protein kinase A disassembles the caspase-9 core.
Authors: SerranoBanyuhay P，HardyJean
Journal: Cell Death Differ.
PubMed ID: 29352269
Doi: 10.1038/s41418-017-0052-9
Products & Services: Mutagenesis Services   
The gating mechanism in cyclic nucleotide-gated ion channels.
Authors: MazzoliniMonica，ArcangelettiManuel，MarchesiArin，NapolitanoLuisa M R，GrosaDebora，MaitySourav，AnselmiClaudio，TorreVin
Journal: Sci Rep
PubMed ID: 29311674
Doi: 10.1038/s41598-017-18499-0
Products & Services: Mutagenesis Services   
Dominant-negative IKZF1 mutations cause a T， B， and myeloid cell combined immunodeficiency.
Authors: BoutboulDavid，KuehnHye Sun，Van de WyngaertZoé，NiemelaJulie E，CallebautIsabelle，StoddardJennifer，LenoirChristelle，BarlogisVincent，FarnarierCatherine，VelyFrédéric，YoshidaNao，KojimaSeiji，KaneganeHirokazu，HoshinoAkihiro，HauckFabian，LhermitteLudovic，AsnafiVahid，RoehrsPhilip，ChenShaoying，VerbskyJames W，CalvoKatherine R，HusamiAmmar，ZhangKejian，RobertsJoseph，AmrolDavid，SleasemanJohn，HsuAmy P，HollandSteven M，MarshRebecca，FischerAlain，FleisherThomas A，PicardCapucine，LatourSylvain，RosenzweigSerg
Journal: J. Clin. Invest.
PubMed ID: 29889099
Doi: 10.1172/JCI98164
Products & Services: Mutagenesis Services   

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