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Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling

Authors: Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu

Journal: Advanced Science

PubMed ID: 40789101

Doi: 10.1002/advs.202509846

Products & Services: Mutagenesis Services

Functional Analysis of the Yeast Counterpart to the Human GCN2 p.Glu738_Asp739insArgArg Variant

Authors: Anja H Schiemann, Makhdoom Sarwar, Evelyn Sattlegger

Journal: microPublication biology

PubMed ID: 40880988

Doi: 10.17912/micropub.biology.001767

Products & Services: Mutagenesis Services

Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain

Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini

Journal: The Journal of Biological Chemistry

PubMed ID: 40651610

Doi: 10.1016/j.jbc.2025.110470

Products & Services: Mutagenesis Services PCR Cloning and Subcloning Gene Synthesis

A single main-chain hydrogen bond required to keep GABAA receptors closed

Authors: Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm

Journal: Nature Communications

PubMed ID: 40603861

Doi: 10.1038/s41467-025-61447-0

Products & Services: Mutagenesis Services

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

Authors: S Arfè, T Karagyozova, A Forest, D Bingham, H Hmidan, D Mazaud, M Garnier, P Le Baccon, E Meshorer, J-P Quivy, G Almouzni

Journal: Nature Communications

PubMed ID: 40461574

Doi: 10.1038/s41467-025-60430-z

Products & Services: Mutagenesis Services

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Authors: Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li

Journal: Nature Communications

PubMed ID: 40527873

Doi: 10.1038/s41467-025-60710-8

Products & Services: Mutagenesis Services

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning Mutagenesis Services

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair

Authors: F Li, A S Phadte, M Bhatia, S Barndt, A R Monte Carlo Iii, C-F D Hou, R Yang, S Strock, A Pluciennik