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H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

Authors: S Arfè, T Karagyozova, A Forest, D Bingham, H Hmidan, D Mazaud, M Garnier, P Le Baccon, E Meshorer, J-P Quivy, G Almouzni

Journal: Nature Communications

PubMed ID: 40461574

Doi: 10.1038/s41467-025-60430-z

Products & Services: Mutagenesis Services

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Authors: Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li

Journal: Nature Communications

PubMed ID: 40527873

Doi: 10.1038/s41467-025-60710-8

Products & Services: Mutagenesis Services

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

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Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair

Authors: F Li, A S Phadte, M Bhatia, S Barndt, A R Monte Carlo Iii, C-F D Hou, R Yang, S Strock, A Pluciennik

Journal: Nature Communications

PubMed ID: 40368897

Doi: 10.1038/s41467-025-59323-y

Products & Services: Mutagenesis Services

Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins

Authors: Justin M Bradley , Zinnia Bugg , Jacob Pullin , Geoffrey R Moore, Dimitri A Svistunenko , Nick E Le Brun

Journal: Nature Communications

PubMed ID: 40393986

Doi: 10.1038/s41467-025-59463-1

Products & Services: Mutagenesis Services

The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin

Authors: Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

Journal: Genes Dev

PubMed ID: 40169231

Doi: 10.1101/gad.352389.124

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Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Authors: Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T Hung, Robert M Stroud

Journal: Nature Communications

PubMed ID: 40169593

Doi: 10.1038/s41467-025-58133-6

Products & Services: Mutagenesis Services

The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

Authors: Andrea Iannucci, Davide Lacarbonara, Valeria Caneparo, Federica Castiglioni, Andrea Butticè, Stefano Raviola, Chiara Porta, Riccardo Miggiano, Ivan Zanoni, Marisa Gariglio, Marco De Andrea

Journal: iScience

PubMed ID: 40454096

Doi: 10.1016/j.isci.2025.112413

Products & Services: Mutagenesis Services

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants

Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters

Journal: nature immunology

PubMed ID: 39930093

Doi: 10.1038/s41590-025-02088-9

Products & Services: Mutagenesis Services

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

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