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Structural insights into Type II-D Cas9 and its robust cleavage activity

Authors: Kangkang Wang, Jiuyu Wang, Xiaoqi Yang, Wei Sun, Gang Sheng, Yanli Wang

Journal: Nature Communications

PubMed ID: 40790018

Doi: 10.1038/s41467-025-62128-8.

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14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

Authors: Juliana A Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D Metcalfe, Mark R Cookson, Ping Zhang

Journal: Nature Communications

PubMed ID: 40764514

Doi: 10.1038/s41467-025-62337-1.

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E. coli-mediated expedient biosynthesis of biotin-labeled ubiquitin probe enables activity-based profiling of deubiquitinases in cytoplasmic and nuclear compartments

Authors: Shuai Peng, Shaowen Wang, Xiaotong Liu, Hongrui Xu, Guoqiang Xu, Jia-bin Li

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.111760

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Viral evolution prediction identifies broadly neutralizing antibodies to existing and rospective SARS-CoV-2 variants

Authors: Fanchong Jian, Anna Z Wec, Leilei Feng, Yuanling Yu, Lei Wang, Peng Wang, Lingling Yu, Jing Wang, Jacob Hou, Daniela Montes Berrueta, Diana Lee, Tessa Speidel, LingZhi Ma, Thu Kim, Ayijiang Yisimayi, Weiliang Song, Lu Liu, Sijie Yang, Xiao Niu, Tianhe Xiao, Ran An, Yao Wang, Fei Shao, Youchun Wang, Simone Pecetta, Xiangxi Wang, Laura M Walker, Yunlong Cao

Journal: Nature Microbiology

PubMed ID: 40494884

Doi: 10.1038/s41564-025-02030-7

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Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes

Authors: Anaxi Houbaert, Valérie Denervaud Tendon, Lukas Hoermayer, Nicholas Morffy, Lucia C Strader, Niko Geldner

Journal: Nature Communications

PubMed ID: 40670339

Doi: 10.1038/s41467-025-61742-w

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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Xiuxia Gao, Yannan Wang, Wenping Shi, Roger D Kornberg, Heqiao Zhang

Journal: Cell

PubMed ID: 40628260

Doi: 10.1016/j.cell.2025.06.017

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A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

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Pol θ-mediated end-joining uses microhomologies containing mismatches

Authors: Yuzhen Li, Ngoc K Dang, Wei He, Mark Returan, Denisse Carvajal-Maldonado, Adele T Guerin, Han Xu, Bin Liu, Richard D Wood

Journal: Nature Communications

PubMed ID: 40603872

Doi: 10.1038/s41467-025-61258-3

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Evaluation of AlphaFold modeling for elucidation of nanobody–peptide epitope interactions

Authors: Shivani Sachdev, Swarnali Roy, Shubhra J Saha, Gengxiang Zhao, Rashmi Kumariya, Brendan A Creemer, Rui Yin, Brian G Pierce, Carole A Bewley, Ross W Cheloha

Journal: The Journal of Biological Chemistry

PubMed ID: 40409557

Doi: 10.1016/j.jbc.2025.110268

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Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing

Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney

Journal: Advanced Science

PubMed ID: 40685751

Doi: 10.1002/advs.202509800

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