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Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

Authors: Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart

Journal: Nat Commun

PubMed ID: 38678031

Doi: 10.1038/s41467-024-47795-3

Products & Services: Gene Synthesis

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Journal: Nature Communications

PubMed ID: 38565883

Doi: 10.1038/s41467-024-47069-y

Products & Services: Gene Synthesis

Mutation of the peptide-regulated transcription factor ComR for amidated peptide specificity and heterologous function in WCFS1

Authors: Michael Brasino, Eli Wagnell, E Sila Ozdemir, Srivathsan Ranganathan, Justin Merritt

Journal: Microbiol Spectr

PubMed ID: 38687019

Doi: 10.1128/spectrum.00517-24

Products & Services: Gene Synthesis

Functional and structural insights into activation of TRPV2 by weak acids

Authors: Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler

Journal: EMBO J

PubMed ID: 38671253

Doi: 10.1038/s44318-024-00106-4

Products & Services: Gene Synthesis

Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin

Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang, Zhuying Li

Journal: BMC Pharmacol Toxicol

PubMed ID: 38650035

Doi: 10.1186/s40360-024-00751-9

Products & Services: Gene Synthesis

Structural analyses of the GI4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies

Authors: Tomomi Kimura-Someya, Kazushige Katsura, Miyuki Kato-Murayama, Toshiaki Hosaka, Tomomi Uchikubo-Kamo, Kentaro Ihara, Kazuharu Hanada, Shin Sato, Kazutaka Murayama, Michiyo Kataoka, Mikako Shirouzu, Yuichi Someya

Journal: J Virol

PubMed ID: 38593321

Doi: 10.1128/jvi.00197-24

Products & Services: Gene Synthesis

Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption

Authors: Andi Yang, Jinmeng Wang, Zhiyu Yang, Lulu Wang, Houxuan Li, Lang Lei

Journal: Int J Med Sci

PubMed ID: 38774749

Doi: 10.7150/ijms.94972

Products & Services: Gene Synthesis

Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

Authors: Krishna D Reddy, Burha Rasool, Farideh Badichi Akher, Nemanja Kutlešić, Swati Pant, Olga Boudker

Journal: biorxiv

PubMed ID: 38106174

Doi: 10.1101/2023.12.03.569786

Products & Services: Gene Synthesis

Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression

Authors: Jesus D Castaño, Irina V El Khoury, Joshua Goering, James E Evans, Jiwei Zhang

Journal: Appl Environ Microbiol

PubMed ID: 38567954

Doi: 10.1128/aem.00122-24

Products & Services: Gene Synthesis

Heterogeneous and Cooperative Rupture of Histidine-Ni Metal-Coordination Bonds on Rationally Designed Protein Templates

Authors: Eesha Khare, Constancio Gonzalez Obeso, Zaira Martín-Moldes, Ayesha Talib, David L Kaplan, Niels Holten-Andersen, Kerstin G Blank, Markus J Buehler

Journal: ACS Biomater Sci Eng

PubMed ID: 38669114

Doi: 10.1021/acsbiomaterials.3c01819

Products & Services: Gene Synthesis