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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

Products & Services: Gene Synthesis Mutagenesis Services PCR Cloning and Subcloning Peptide Synthesis

ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental Cell

Doi: 10.1016/j.devcel.2025.03.005

Products & Services: Gene Synthesis Protein Electrophoresis and Western

Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists

Authors: Xiaohong Sang, Haizhan Jiao, Qian Meng, Xiong Fang, Qi Pan, Jiao Zhou, Tingli Qian, Wanqin Zhang, Yan Xu, Jing An, Ziwei Huang, Hongli Hu

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40063796

Doi: 10.1073/pnas.2425795122

Products & Services: Gene Synthesis

Immunomodulatory role of the stem cell circadian clock in muscle repair

Authors: Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R Gupta, Ariana Kupai, Amber Willbanks, Richard L Lieber, Ishan Roy, Navdeep S Chandel, Clara B Peek

Journal: SCIENCE ADVANCES

PubMed ID: 40043110

Doi: 10.1126/sciadv.adq8538

Products & Services: Gene Synthesis

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Authors: Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng

Journal: Nature Communications

PubMed ID: 40069234

Doi: 10.1038/s41467-025-57886-4

Products & Services: Gene Synthesis

Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440

Authors: Blas Blázquez, Juan Nogales

Journal: Microbial biotechnology

PubMed ID: 40126873

Doi: 10.1111/1751-7915.70132

Products & Services: Gene Synthesis

Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

Products & Services: Codon Optimization Gene Synthesis

Activation of the bacterial defenseassociated sirtuin system

Authors: Kaixiang Zhu, Kun Shang, Linyue Wang, Xia Yu, Lei Hua, Weihe Zhang, Bo Qin, Jia Wang, Xiaopan Gao, Hongtao Zhu, Sheng Cui

Journal: Communications Biology

PubMed ID: 39994439

Doi: doi.org/10.1038/s42003-025-07743-3

Products & Services: Gene Synthesis

Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma

Authors: Yiliang Jin, Baoli Zhang, Jianru Li, Zhenxi Guo, Chen Zhang, Xuehui Chen, Long Ma, Zhuoran Wang, Haiyin Yang, Yong Li, Yuhua Weng, Yuanyu Huang, Xiyun Yan, Kelong Fan

Journal: SCIENCE ADVANCES

PubMed ID: 39970222

Doi: 10.1126/sciadv.adr9266

Products & Services: Gene Synthesis

Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system

Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang

Journal: Nat Commun

PubMed ID: 39984501

Doi: 10.1038/s41467-025-57153-6

Products & Services: Gene Synthesis