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Clinical assays rapidly predict bacterial susceptibility to monoclonal antibody therapy

Authors: Matthew J Slarve, Neven Bowler, Elizabeth Burk, Jun Yan, Ulrike Carlino-MacDonald, Thomas A Russo, Brian M Luna, Brad Spellberg

Journal: JCI Insight

PubMed ID: 38258902

Doi: 10.1172/jci.insight.174799

Products & Services: Gene Synthesis

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao

Journal: Nature

PubMed ID: 37993710

Doi: 10.1038/s41586-023-06753-7

Products & Services: Gene Synthesis

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Doi: 10.1038/s41594-023-01146-w

Products & Services: Peptide Synthesis Gene Synthesis

Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Authors: Mingyang Li , Mengyuan Liu , Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou and Guoyang Liao

Journal: Vaccine

Doi: 10.3390/vaccines12030300

Products & Services: Gene Synthesis

PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Authors: Nagaraja Chappidi 1, Thomas Quail 2, Simon Doll 3, Laura T Vogel 4, Radoslav Aleksandrov 5, Suren Felekyan 4, Ralf Kühnemuth 4, Stoyno Stoynov 5, Claus A M Seidel 4, Jan Brugués 6, Marcus Jahnel 3, Titus M Franzmann 1, Simon Alberti

Journal: Cell

PubMed ID: 38320550

Doi: 10.1016/j.cell.2024.01.015

Products & Services: Codon Optimization Gene Synthesis

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors: Sabine Poerschke, Silke Oeljeklaus, Luis Daniel Cruz-Zaragoza, Alexander Schenzielorz, Drishan Dahal, Hauke Sven Hillen, Hirak Das, Laura Sophie Kremer, Anusha Valpadashi, Mirjam Breuer, Johannes Sattmann, Ricarda Richter-Dennerlein, Bettina Warscheid, Sven Dennerlein, Peter Rehling

Journal: Cell

PubMed ID: 38199007

Doi: 10.1016/j.molcel.2023.12.013

Products & Services: Gene Synthesis

Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou

Journal: Nat Commun

PubMed ID: 38168054

Doi: 10.1038/s41467-023-44461-y

Products & Services: Gene Synthesis

Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

Authors: Paolo Pizzul, Erika Casari, Carlo Rinaldi, Marco Gnugnoli, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Journal: Nucleic Acids Res

PubMed ID: 38180815

Doi: 10.1093/nar/gkad1246

Products & Services: Gene Synthesis

LATS2 condensates organize signalosomes for Hippo pathway signal transduction

Authors: Min Qin, Ershuo Geng, Jingning Wang, Man Yu, Tianqi Dong, Shasha Li, Xiao Zhang, Jiaming Lin, Mingjun Shi, Juebei Li, Huixia Zhang, Lian Chen, Xiaolei Cao, Liu Huang, Mingwei Wang, Yan Li, Xiang-ping Yang, Bin Zhao & Shuguo Sun

Journal: Nature Chemical Biology

PubMed ID: 38200110

Doi: 10.1038/s41589-023-01516-x

Products & Services: Gene Synthesis

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Authors: Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza

Journal: Pharmaceutics

PubMed ID: 38258126

Doi: 10.3390/pharmaceutics16010116

Products & Services: Gene Synthesis