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Mining and rational design of psychrophilic catalases using metagenomics and deep learning models

Authors: Shuning Wu, Guoshun Xu, Yongping Su, Huoqing Huang, Xinxin Xu, Yuhong Zhang, Jian Tian, Wei Zhang, Zhiwei Zhang, Bo Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 38175233

Doi: 10.1007/s00253-023-12926-1

Products & Services: Gene Synthesis

A high catalytic efficiency and chemotolerant formate dehydrogenase from Bacillus simplex

Authors: Rattima Boonkumkrong, Paweenapon Chunthaboon, Pobthum Munkajohnpong, Pratchaya Watthaisong, Panu Pimviriyakul, Somchart Maenpuen, Pimchai Chaiyen, Ruchanok Tinikul

Journal: Biotechnol J

PubMed ID: 38180313

Doi: 10.1002/biot.202300330

Products & Services: Gene Synthesis

Increasing β-hexosaminidase A activity using genetically modified mesenchymal stem cells

Authors: Alisa A Shaimardanova , Daria S Chulpanova , Valeriya V Solovyeva 1, Shaza S Issa , Aysilu I Mullagulova , Angelina A Titova , Yana O Mukhamedshina , Anna V Timofeeva , Alexander M Aimaletdinov , Islam R Nigmetzyanov , Albert A Rizvanov

Journal: Neural Regen Res .

PubMed ID: 37488869

Doi: 10.4103/1673-5374.375328

Products & Services: Gene Synthesis

Stabilization of the Metastable Pre-Fusion Conformation of the SARS-CoV-2 Spike Glycoprotein through N-Linked Glycosylation of the S2 Subunit

Authors: Fuwen Zan, Yao Zhou, Ting Chen , Yahan Chen, Zhixia Mu, Zhaohui Qian , Xiuyuan Ou

Journal: Viruses.

PubMed ID: 38399999

Doi: 10.3390/v16020223

Products & Services: Gene Synthesis

TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing

Authors: Kostantin Kiianitsa, Maria E Lukes, Brian J Hayes, Julianna Brutman, Paul N Valdmanis, Thomas D Bird, Wendy H Raskind, Olena Korvatska

Journal: Brain

PubMed ID: 38226698

Doi: 10.1093/brain/awae014

Products & Services: Gene Synthesis Mutagenesis Services Plasmid DNA Preparation

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Authors: Thomas E Mulroney, Tuija Pöyry, Juan Carlos Yam-Puc, Maria Rust, Robert F Harvey, Lajos Kalmar, Emily Horner, Lucy Booth, Alexander P Ferreira, Mark Stoneley, Ritwick Sawarkar, Alexander J Mentzer, Kathryn S Lilley, C Mark Smales, Tobias von der Haar, Lance Turtle, Susanna Dunachie, Paul Klenerman, James E D Thaventhiran, Anne E Willis

Journal: Nature

PubMed ID: 38057663

Doi: 10.1038/s41586-023-06800-3

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Neutralisation activity of mucosal IgA against XBB sublineages and BA.2.86

Authors: Fanglei Zuo, Yunlong Cao, Rui Sun, Ayijiang Yisimayi, Likun Du, Federico Bertoglio, Maren Schubert, Concetta Guerra, Andrea Cavalli, Michael Hust, Davide F Robbiani, Hassan Abolhassani, Xiaoliang Sunney Xie, Lennart Hammarström, Harold Marcotte, Qiang Pan-Hammarström

Journal: The Lancet. Infectious diseases

PubMed ID: 38071989

Doi: 10.1016/S1473-3099(23)00732-6

Products & Services: Gene Synthesis Codon Optimization

Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate

Authors: Sander F Garrelfs, Serhii Chornyi, Heleen Te Brinke, Jos Ruiter, Jaap Groothoff, Ronald J A Wanders

Journal: J Inherit Metab Dis

PubMed ID: 38200664

Doi: 10.1002/jimd.12711

Products & Services: Gene Synthesis

A novel starch-active lytic polysaccharide monooxygenase discovered with bioinformatics screening and its application in textile desizing

Authors: Meijuan Zhang, Xiaoping Fu, Rongrong Gu, Bohua Zhao, Xingya Zhao, Hui Song, Hongchen Zheng, Jianyong Xu, Wenqin Bai

Journal: BMC Biotechnol

PubMed ID: 38200466

Doi: 10.1186/s12896-023-00826-1

Products & Services: Gene Synthesis

Towards detection of structurally-diverse glycated epitopes in native proteins: Single-chain antibody directed to non-A1c epitope in human haemoglobin

Authors: Miss Lucia Gaetani, Isabel Campos Pinto, Meng Li, Peter O'Connor, Susan Giorgi-Coll, Matthew Tyreman, Katherine L Rumary, James A Schouten, Paul Davis, Ann M Dixon

Journal: Mol Immunol

PubMed ID: 38181455

Doi: 10.1016/j.molimm.2023.12.008

Products & Services: Gene Synthesis