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Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy

Authors: Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong

Journal: J Med Chem

PubMed ID: 38624086

Doi: 10.1021/acs.jmedchem.3c02240

Products & Services: Gene Synthesis

The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine

Authors: Michele A Kutzler, Gina Cusimano, David Joyner, Emily Konopka, Roshell Muir, Philip Barnette, Melanie Guderian, Iván Del Moral-Sánchez, Ronald Derking, Tom Bijl, Jonne Snitselaar, Photis Rotsides, Kyra Woloszczuk, Matthew Bell, Gabriela Canziani, Irwin Chaiken, Ann Hessell, Yannic Bartsch, Rogier Sanders, Elias Haddad

Journal: Res Sq

PubMed ID: 38746176

Doi: 10.21203/rs.3.rs-4139764/v1

Products & Services: Gene Synthesis

Identification of hyperthermophilic D-allulose 3-epimerase from Thermotoga sp and its application as a high-performance biocatalyst for D-allulose synthesis

Authors: Ji-Dong Shen, Bao-Ping Xu, Te-Li Yu, Yong-Xiang Fei, Xue Cai, Liang-Gang Huang, Li-Qun Jin, Zhi-Qiang Liu, Yu-Guo Zheng

Journal: Bioprocess Biosyst Eng

PubMed ID: 38676737

Doi: 10.1007/s00449-024-02989-3

Products & Services: Gene Synthesis

The Female-Biased General Odorant Binding Protein 2 of Displays Binding Affinity for Biologically Active Host Plant Volatiles

Authors: Jingjing Tu, Zehua Wang, Fan Yang, Han Liu, Guanghang Qiao, Aihuan Zhang, Shanning Wang

Journal: Biology (Basel)

PubMed ID: 38666886

Doi: 10.3390/biology13040274

Products & Services: Gene Synthesis

Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

Authors: Lijie Guo, Pingping Huang, Zhaoxing Li, Young-Cheul Shin, Purui Yan, Meiling Lu, Meirong Chen, Yibei Xiao

Journal: Nat Chem Biol

PubMed ID: 37932527

Doi: 10.1038/s41589-023-01478-0

Products & Services: Molecular Biology Reagents Gene Synthesis

Engineering allorejection-resistant CAR-NKT cells from hematopoietic stem cells for off-the-shelf cancer immunotherapy

Authors: Yan-Ruide Li, Yang Zhou 1, Jiaji Yu, Yichen Zhu, Derek Lee, Enbo Zhu, Zhe Li, Yu Jeong Kim, Kuangyi Zhou, Ying Fang, Zibai Lyu, Yuning Chen, Yanxin Tian, Jie Huang, Xinjian Cen, Tiffany Husman, Jae Min Cho, Tzung Hsiai, Jin J Zhou, Pin Wang, Benjamin R Puliafito, Sarah M Larson, Lili Yang

Journal: Molecular Therapy

PubMed ID: 38584391

Doi: 10.1016/j.ymthe.2024.04.005

Products & Services: Gene Synthesis

AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans

Authors: Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia Maysel-Auslender, Holden T Maecker, Hady Samaha, Nadine Rouphael, Ian A Wilson, Alberto C Moreno, Mehul S Suthar, Surender Khurana, Stéphane Pillet, Nathalie Charland, Brian J Ward, Bali Pulendran

Journal: Science immunology

PubMed ID: 38579013

Doi: 10.1126/sciimmunol.adi8039

Products & Services: Gene Synthesis

Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination

Authors: Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S Symington, Petr Cejka, Boris Pfander

Journal: Nature Communications

PubMed ID: 38570537

Doi: 10.1038/s41467-024-46951-z

Products & Services: Gene Synthesis

A selective Fibroblast Growth Factor Receptor 1/2 PROTAC degrader with 1 antitumor activity

Authors: Ying Kong , Xinyue Zhao , Zhaofu Wang , Siqi Yuan , Sheng Chen , Shidi Lou , Shichao Ma , Yunfeng Li , Xinghao Wang , Yangfeng Ge , Guobin Li , Hongbing Yang , Mengxi Zhao , Dandan Li , Hailong Zhang , Wenfu Tan , Juan Wang

Journal: Molecular cancer therapeutics

PubMed ID: 38647531

Doi: 10.1158/1535-7163.MCT-23-0719

Products & Services: Gene Synthesis

Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin

Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang, Zhuying Li

Journal: BMC Pharmacol Toxicol

PubMed ID: 38650035

Doi: 10.1186/s40360-024-00751-9

Products & Services: Gene Synthesis