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Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery

Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen

Journal: The Journal of Biological Chemistry

PubMed ID: 39880089

Doi: 10.1016/j.jbc.2025.108237

Products & Services: Gene Synthesis Codon Optimization

Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β

Authors: Tyler M Weaver, Benjamin J Ryan, Spencer H Thompson, Adil S Hussen, Jonah J Spencer, Zhen Xu, Nicholas J Schnicker, Bret D Freudenthal

Journal: Nature Communications

PubMed ID: 40097433

Doi: 10.1038/s41467-025-57915-2

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Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

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RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites

Authors: Juan Huang, Juan Du, Yan Liu, Lu Lu, Yanzhuo Xu, Jianfei Shi, Qing Liu, Qi Li, Yang Liu, Yaqiu Chen, Meng Du, Yiming Zhao, Liangxiao Huo, Weiran Wang, Chenxi Ding, Liya Wei, Jianguo Wu, Yao-Wu Yuan, Jinfeng Chen, Ruixi Li, Feng Cui, Xiaoming Zhang

Journal: Nature Communications

PubMed ID: 40000658

Doi: 10.1038/s41467-025-57296-6

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Structure of the tilapia lake virus nucleoprotein bound to RNA

Authors: Benoît Arragain, Martin Pelosse, Karine Huard, Stephen Cusack

Journal: Nucleic Acids Res

PubMed ID: 39995042

Doi: 10.1093/nar/gkaf112

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Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

Authors: Cheng-Bao Ma, Chen Liu, Young-Jun Park, Jingjing Tang, Jing Chen, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Zheng-Li Shi, Zengqin Deng, David Veesler, Huan Yan

Journal: Cell

PubMed ID: 39922191

Doi: 10.1016/j.cell.2024.12.031

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Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

Authors: Young-Jun Park, Chen Liu, Jimin Lee, Jack T Brown, Cheng-Bao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K Zepeda, Cameron Stewart, Amin Addetia, Caroline J Craig, M Alejandra Tortorici, Abeer N Alshukairi, Tyler N Starr, Huan Yan, David Veesler

Journal: Cell

PubMed ID: 39922192

Doi: 10.1016/j.cell.2024.12.032

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Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates

Authors: Prakash Jadhav, Xueying Liang, Ahmadullah Ansari, Bin Tan, Haozhou Tan, Kan Li, Xiang Chi, Alexandra Ford, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang

Journal: Nature Communications

PubMed ID: 39948104

Doi: 10.1038/s41467-025-56902-x

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Dual functional POGases from bacteria encompassing broader O-glycanase and adhesin activities

Authors: Linjiao Zhou, Uriel Ortega-Rodriguez, Matthew J Flores, Yasuyuki Matsumoto, John Q Bettinger, Wells W Wu, Yaqin Zhang, Su-Ryun Kim, Thomas G Biel, Jordan D Pritts, Rong-Fong Shen, V Ashutosh Rao, Tongzhong Ju.

Journal: Nature Communications

PubMed ID: 40000644

Doi: 10.1038/s41467-025-57143-8

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Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I

Authors: Bryan Neumann, Stephen McCarthy, Shane Gonen

Journal: Nature Communications

PubMed ID: 39920100

Doi: 10.1038/s41467-024-55764-z

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