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DLL3, His, Rhesus macaque

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
￥3200
Z03949-100

产品简介
Species Rhesus macaque
Protein Construction
His DLL3 (Ala27-Arg490)
Accession # F6TFV4
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized DLL3, His, Rhesus macaque (Cat.No.: Z03949) at 1 μg/ml (100μl/Well) on the plate can bind Anti-DLL3 Antibody, hFc Tag
Expression System HEK293
Theoretical Molecular Weight 51 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM Tris, 50mM NaCl, 200mM L-arginine (pH 8.5) / PBS (pH 7.4).
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
DLL3, His, Rhesus Macaque

Immobilized DLL3, His, Rhesus macaque at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 2.6 ng/ml determined by ELISA. »

DLL3, His, Rhesus Macaque

The purity of DLL3, His, Rhesus macaque is greater than 95% as determined by SEC-HPLC. »

DLL3, His, Rhesus Macaque

DLL3, His, Rhesus macaque on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand. It is highly expressed on the surface of Small cell lung cancer (SCLC) and other neuroendocrine tumors. And its expression promotes SCLC migration and invasion. DLL3 agents are evaluated in several ongoing clinical studies in SCLC and other neuroendocrine tumors.
Synonyms Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.