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PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

Products & Services: Catalog Peptides

Gas Chromatography-Mass Spectrometry Metabolite Analysis Combined with Transcriptomic and Proteomic Provide New Insights into Revealing Cuticle Formation during Pepper Development

Authors: Shuai Ge, Keying Qin, Shenghua Ding, Jianfeng Yang, Liwen Jiang, Yeyou Qin, Rongrong Wang

Journal: J Agric Food Chem

PubMed ID: 36148491

Doi: 10.1021/acs.jafc.2c04522

Products & Services: Proteins, Expression, Isolation and Analysis

Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism

Authors: Ni Liu, Xiaohan Liang, Changwen Yang, Shun Hu, Qingming Luo, Haiming Luo

Journal: Theranostics

PubMed ID: 36185606

Doi: 10.7150/thno.76574

Products & Services: Proteins, Expression, Isolation and Analysis

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Authors: Eric S Pringle, Brett A Duguay, Maxwell P Bui-Marinos, Rory P Mulloy, Shelby L Landreth, Krishna Swaroop Desireddy, Stacia M Dolliver, Shan Ying, Taylor Caddell, Trinity H Tooley, Patrick D Slaine, Stephen L Bearne, Darryl Falzarano, Jennifer A Corcoran, Denys A Khaperskyy, Craig McCormick

Journal: PLoS Pathog

PubMed ID: 36121863

Doi: 10.1371/journal.ppat.1010832

Products & Services: PCR Cloning and Subcloning

Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

Products & Services: Proteins, Expression, Isolation and Analysis

Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs

Authors: Jane X Yeh, Yunfan Fan, Maggie L Bartlett, Xiaoyan Zhang, Norah Sadowski, Debra A Hauer, Winston Timp, Diane E Griffin

Journal: MBio

PubMed ID: 36069441

Doi: 10.1128/mbio.02221-22

Products & Services: Plasmid DNA Preparation

SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

Products & Services: Proteins, Expression, Isolation and Analysis

Lymphocyte Subpopulations Associated with Neutralizing Antibody Levels of SARS-CoV-2 for COVID-19 Vaccination

Authors: Wan-Ting Huang, Shao-Wen Weng, Hong-Tai Tzeng, Feng-Chun Yen, Yu-Shao Chiang, Huey-Ling You

Journal: Vaccines (Basel)

PubMed ID: 36146627

Doi: 10.3390/vaccines10091550

Products & Services: Recombinant Proteins

A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies

Authors: Meiniang Wang, Likun Wei, Haitao Xiang, Bingzhao Ren, Xiaopan Liu, Lin Jiang, Naibo Yang, Jiahai Shi