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Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy

Authors: Kimberly J Nelson, Terrence L Smalley Jr, Terri Messier, Rajesh Gumpena, Uma Gandhi, Stephanie Milczarek, Aida Habibovic, Hattie Hoffman, Victoria Gibson, Robert J Hondal, W Todd Lowther, Brian Cunniff

Journal: SCIENCE ADVANCES

PubMed ID: 41171914

Doi: 41171914

The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection

Authors: Tai-Ting Woo, Yuka Takeo, Mara C Harwood, Ethan T Houck, Daniel DiMaio, Billy Tsai

Journal: SCIENCE ADVANCES

PubMed ID: 41124246

Doi: 10.1126/sciadv.adz6792

Discovery of a Serine-Directed Chemical Reaction for Site-Specific Protein Modification via Phage Display Screening

Authors: Yingjie Lei, Kai Zhao, Mengzhun Guo, Liang Guo, Jinfeng Chen, Mengjiao Li, Dandan Liu, Kai Chen, Jiahao Mei, Tian Li, Bing Yang, Jing Huang, Bobo Dang

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 41108661

Doi: doi.org/10.1002/anie.202514412

Products & Services: Protein and Antibody Isolation

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Authors: Man Wang, Ziyu Zhang, Xiaohan Wang, Liyan Zhang, Xiangyan Chen, Nianci Li, Qiuhan Sun, Yicheng Lu, Zuhong He, Hongbo Yang, Fangzhi Tan, Jieyu Qi, Renjie Chai

Journal: Nature Communications

PubMed ID: 40968144

Doi: 10.1038/s41467-025-63613-w.

Products & Services: Protein and Antibody Isolation

Multifunctional NAC transcription factor SlJA2L integrates the ethylene pathway to orchestrate thermotolerance and fruit ripening in tomato

Authors: Yunfei Liang, Fang Ma, Shudi Huang, Chao Ma, Hongyan Shi, Fanyi Meng, Yinglu Chen, Han Dong, Rugang Chen, Xiangqiang Zhan

Journal: New Phytologist

PubMed ID: 40963426

Doi: 10.1111/nph.70571

Products & Services: Catalog Antibodies

The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses

Authors: Kira Schamoni-Kast, Boris Krichel, Tomislav Damjanović, Fatema-Aqila Said, Thomas Kierspel, Sibel Toker, Charlotte Uetrecht

Journal: Nature Communications

PubMed ID: 40925907

Doi: 10.1038/s41467-025-61554-y.

Products & Services: Gene Services

Ultrastrong Staphylococcus aureus adhesion to human skin: Calcium as a key regulator of noncovalent interactions

Authors: Constance Chantraine, Priscila S F C Gomes, Marion Mathelié-Guinlet, Diego E B Gomes, Zhiyong Zheng, Julianne Clowry, Mary B Turley, Alan D Irvine, Joan A Geoghegan, Rafael C Bernardi, Yves F Dufrêne

Journal: SCIENCE ADVANCES

PubMed ID: 40901964

Doi: 10.1126/sciadv.adu7457

SLC25A39 overexpression exacerbates lung adenocarcinoma progression and is negatively regulated by AFG3L2

Authors: Wenxuan Hu, Jian Yang, Zhike Chen, Yongsen Li, Gaomeng Luo, Kang Hu, Zihao Lu, Xin Lv, Yonghao Cao, Haoyang Yuan, Cong Cao, Jun Zhao, Chun Xu

Journal: NPJ precision oncology

PubMed ID: 40993178

Doi: 10.1038/s41698-025-01081-7

Products & Services: Protein and Antibody Isolation

A reproducible hybrid membrane for in situ analysis of cell secretions with a wide size range

Authors: Zixuan Chen, Yafeng Wu, Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Songqin Liu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.110917

Products & Services: Recombinant Proteins

Computational design of potent and selective binders of BAK and BAX

Authors: Stephanie Berger, Erinna F Lee, Tiffany J Harris, Sharon Tran, Asim K Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S Miller, Sean Smyth, Mariam Lutfi, Rachel T Uren, Ruth M Kluck, Peter M Colman, Walter D Fairlie, Peter E Czabotar, David Baker, Richard W Birkinshaw

Journal: SCIENCE ADVANCES

PubMed ID: 40911686

Doi: 10.1126/sciadv.adt4170

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