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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition

Authors: Eric T Baldwin, Matthias Götte, Egor P Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L Romero

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35771941

Doi: 10.1073/pnas.2200260119

Products & Services: Codon Optimization

TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules

Authors: Andrew C McShan, Christine A Devlin, Georgia F Papadaki, Yi Sun, Adam I Green, Giora I Morozov, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Nat Chem Biol

PubMed ID: 35725941

Doi: 10.1038/s41589-022-01049-9

Products & Services: Catalog Peptides

Tailored protein-conjugated DNA nanoplatform for synergistic cancer therapy

Authors: Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 35452765

Doi: 10.1016/j.jconrel.2022.04.022

Products & Services: Gene Synthesis

Structural and mechanistic insights into the inhibition of type I-F CRISPR-Cas system by anti-CRISPR protein AcrIF23

Authors: Junhui Ren, Hao Wang, Lingguang Yang, Feixue Li, Yao Wu, Zhipu Luo, Zeliang Chen, Yi Zhang, Yue Feng

Journal: J Biol Chem

PubMed ID: 35697070

Doi: 10.1016/j.jbc.2022.102124

Products & Services: Mutant Libraries

Recombinant Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats

Authors: Zhiqian Bi, Enqing Cui, Yingying Yao, Xiaoyao Chang, Xiaoyang Wang, Yuhui Zhang, Gen-Xing Xu, Hongqin Zhuang, Zi-Chun Hua

Journal: Front Microbiol

PubMed ID: 35847065

Doi: 10.3389/fmicb.2022.927277

Products & Services: Mammalian Expression

CRISPR/CasRx-Mediated RNA Knockdown Reveals That ACE2 Is Involved in the Regulation of Oligodendroglial Cell Morphological Differentiation

Authors: Yukino Kato, Kenji Tago, Shoya Fukatsu, Miyu Okabe, Remina Shirai, Hiroaki Oizumi, Katsuya Ohbuchi, Masahiro Yamamoto, Kazushige Mizoguchi, Yuki Miyamoto, Junji Yamauchi

Journal: Noncoding RNA

PubMed ID: 35736639

Doi: 10.3390/ncrna8030042

Products & Services: Custom Vector Construction

Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation

Authors: Mohd Moin Khan, Meraj Hasan Khan, Ubaid Ullah Kalim, Sofia Khan, Sini Junttila, Niklas Paulin, Lingjia Kong, Omid Rasool, Laura L Elo, Riitta Lahesmaa

Journal: Front Immunol

PubMed ID: 35784351

Doi: 10.3389/fimmu.2022.856762

Products & Services: Plasmid DNA Preparation

Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes

Authors: Xi Yu, Liangqin Tong, Liming Zhang, Yun Yang, Xiaoping Xiao, Yibin Zhu, Penghua Wang, Gong Cheng

Journal: PLoS Pathog

PubMed ID: 35679229

Doi: 10.1371/journal.ppat.1010552

Products & Services: Endotoxin Detection & Removal System

PBP1 plays key roles in sex pheromone reception of the fall armyworm

Authors: Yongzhi Zhong, Minghui Xie, Zhongjuan Di, Fengqi Li, Jiaqi Chen, Xiangxin Kong, Lulu Lin, Weihua Su, Lina Xu, Feng Zhang, Rui Tang, Haoliang Chen

Journal: Int J Biol Macromol

PubMed ID: 35709868

Doi: 10.1016/j.ijbiomac.2022.06.068

Products & Services: Protein and Antibody Isolation

Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT

Authors: Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L A Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A Priestman, Frances M Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R Morales, Alexey V Pshezhetsky

Journal: J Exp Med

PubMed ID: 35704026

Doi: 10.1084/jem.20211860

Products & Services: Recombinant Antibody Expression

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