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Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15

Authors: Manashi Sonowal, Gihan Ketawala, Nirupa Nagaratnam, Dhenugen Logeswaran, Shibom Basu, Daniele de Sanctis, Julien Orlans, Samuel L Rose, Rebecca J Jernigan, Hao Hu, Jose Domingo Meza Aguilar, Madurangi E Ranaweera, Michele A Zacks, Julian J-L Chen, Debra T Hansen, Lynn G Schrag, Raimund Fromme, Sabine Botha, Petra Fromme

Journal: Protein Science

PubMed ID: 40411374

Doi: 10.1002/pro.70115

Products & Services: Plasmids for SARS-CoV-2 Detection and Research Custom DNA/RNA Oligos

Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma

Authors: Jie Liu, Yuandong Liu, Dongmin Yin, Yang Tian

Journal: Cell chemical biology

PubMed ID: 40466640

Doi: 10.1016/j.chembiol.2025.05.002

Products & Services: Gene Synthesis

Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy

Authors: Chris van Ewijk, Greeshma Jain, Yari K Knelissen, Sourav Maity, Patrick C A van der Wel, Wouter H Roos

Journal: J Am Chem Soc

PubMed ID: 40505012

Doi: 10.1021/jacs.5c05571

Products & Services: Plasmid DNA Preparation

Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance

Authors: Reut Tzemach, Chamutal Gur, Truong San Phan, Eyal David, Mor Zada, Merav D Shmueli, Kfir Mazuz, Fadi Sheban, Anna Kurilovich, Maya Ben Yehuda, Victoria Furer, Ari Polachek, Smadar Gertel, Nimrod Snir, Tali Eviatar, Sharon Nevo, Yifat Merbl, Daphna Paran, Shuang-Yin Wang, Ori Elkayam, Ido Amit

Journal: Science immunology

PubMed ID: 40478933

Doi: 10.1126/sciimmunol.adu0284

Products & Services: Protein Electrophoresis and Western

Antagonistic Ghd7-OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice

Authors: Guangming Lou, Pingli Chen, Pingbo Li, Haozhou Gao, Jiawang Xiong, Shanshan Wan, Yuanyuan Zheng, Yufu Wang, Mufid Alam, Yingnanjun Chen, Lei Wang, Jingjing Bai, Xuan Tan, Wenting Rao, Bian Wu, Hao Zhou, Yanhua Li, Guanjun Gao, Qinglu Zhang, Jinghua Xiao, Xianghua Li, Xuelei Lai, Qifa Zhang, Yuqing He

Journal: Advanced Science

PubMed ID: 40492375

Doi: 10.1002/advs.202504163

Products & Services: Catalog Antibodies

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

Authors: Ran Chen, Bin Liu, Dawid Jaślan, Lucija Kucej, Veronika Kudrina, Belinda Warnke, Yvonne E Klingl, Arnas Petrauskas, Sandra Prat Castro, Kenji Maeda, Christian Grimm, Marja Jäättelä

Journal: Nature Communications

PubMed ID: 40473625

Doi: 10.1038/s41467-025-60349-5

Products & Services: PCR Cloning and Subcloning

The SH protein of mumps virus is a druggable pentameric viroporin

Authors: Kira Devantier, Trine L Toft-Bertelsen, Andreas Prestel, Viktoria M S Kjær, Cagla Sahin, Marco Giulini, Stavroula Louka, Katja Spiess, Asmita Manandhar, Katrine Qvortrup, Trond Ulven, Bo H Bentzen, Alexandre Mjj Bonvin, Nanna MacAulay, Birthe B Kragelund, Mette M Rosenkilde

Journal: SCIENCE ADVANCES

PubMed ID: 40479045

Doi: 10.1126/sciadv.ads3071

Products & Services: Bacterial Expression

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Authors: Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li

Journal: Advanced Science

Doi: 10.1002/advs.202501384

Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking

Authors: Akanksha Thawani, Anthony Rodríguez-Vargas, Briana Van Treeck, Nozhat T Hassan, David L Adelson, Eva Nogales, Kathleen Collins

Journal: SCIENCE ADVANCES

PubMed ID: 40540573

Doi: 10.1126/sciadv.adu5533

Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

Products & Services: Gene Synthesis Codon Optimization

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