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Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Authors: Ole A Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A Howard

Journal: Commun Biol

PubMed ID: 33686177

Doi: 10.1038/s42003-021-01790-2

Products & Services: Catalog Antibodies

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

Authors: Neville Kielau Kisalu, Lais Da Silva Pereira, Keenan J Ernste, Yevel Flores-Garcia, Azza H Idris, Mangaiarkarasi Asokan, Marlon Dillon, Scott MacDonald, Wei Shi, Xuejun Chen, Amarendra Pegu, Arne Schön, Fidel Zavala, Alejandro B Balazs, Joseph R Francica, Robert A Seder

Journal: JCI Insight

PubMed ID: 33332286

Doi: 10.1172/jci.insight.143958

Products & Services: Mutagenesis Services

An Omalizumab Biobetter Antibody With Improved Stability and Efficacy for the Treatment of Allergic Diseases

Authors: Peipei Liu, Zhongzong Pan, Chunyin Gu, Xiaodan Cao, Xiaowu Liu, Jianjian Zhang, Zheng Xiao, Xueping Wang, Haibing Guo, Dianwen Ju, Su-Jun Deng

Journal: Front Immunol

PubMed ID: 33329588

Doi: 10.3389/fimmu.2020.596908

Products & Services: Protein and Antibody Isolation

Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity

Authors: Jong Youl Lee, Taehoon Park, Eunmi Hong, Reeju Amatya, Kyung-Ah Park, Young-Hoon Park, Kyoung Ah Min, Minki Jin, Sumi Lee, Seungmi Hwang, Gu Seob Roh, Meong Cheol Shin

Journal: Biomaterials

PubMed ID: 32736262

Doi: 10.1016/j.biomaterials.2020.120250

Products & Services: Gene Synthesis

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

Authors: Björn Weström, Ester Arévalo Sureda, Kateryna Pierzynowska, Stefan G Pierzynowski, Francisco-José Pérez-Cano

Journal: Front Immunol

PubMed ID: 32582216

Doi: 10.3389/fimmu.2020.01153

Products & Services: Recombinant Proteins

Novel ACE2-IgG1 fusions with increased activity against SARS-CoV-2

Authors: Naoki Iwanaga, Laura Cooper, Lijun Rong, Brandon Beddingfield, Jackelyn Crabtree, Ralph A. Tripp, View ORCID ProfileJay K. Kolls

Journal: biorxiv

Doi: 10.1101/2020.06.15.152157

Products & Services: Gene Synthesis

A single-valent long-acting human CD47 antagonist enhances antibody directed phagocytic activities

Authors: Fenglan Wu, Yangsheng Qiu, Yuhong Xu

Journal: Cancer Immunol Immunother

PubMed ID: 32583154

Doi: 10.1007/s00262-020-02640-6

Products & Services: Custom Vector Construction

Serum albumin‐binding VHHs with variable pH sensitivities enable tailored half‐life extension of biologics

Authors: Henk van Faassen Shannon Ryan Kevin A. Henry Shalini Raphael Qingling Yang Martin A. Rossotti Eric Brunette Susan Jiang Arsalan S. Haqqani Traian Sulea C. Roger MacKenzie … See all authors First publishe

Journal: The FASEB Journal

Doi: 10.1096/fj.201903231R

Products & Services: Gene Synthesis

Structure-Based Design and Discovery of a Long-Acting Cocaine Hydrolase Mutant with Improved Binding Affinity to Neonatal Fc Receptor for Treatment of Cocaine Abuse

Authors: Zheng F, Chen X, Kim K, Zhang T, Huang H, Zhou S, Zhang J, Jin Z, Zhan CG

Journal: The AAPS journal

PubMed ID: 32189158

Doi: 10.1208/s12248-020-00442-3

Products & Services: PCR Cloning and Subcloning

Isolation and Identification of Porcine Deltacoronavirus and Alteration of Immunoglobulin Transport Receptors in the Intestinal Mucosa of PDCoV-Infected Piglets

Authors: Qian S, Jia X, Gao Z, Zhang W, Xu Q,,, Li Z,,.

Journal: Viruses

PubMed ID: 31936476

Products & Services: Gene Synthesis

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