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49 条搜索结果 for FcRn
Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452
Authors: David G Alleva, Andrea R Delpero, Melanie M Scully, Sylaja Murikipudi, Ramya Ragupathy, Emma K Greaves, Thillainaygam Sathiyaseelan, Jeffrey R Haworth, Nishit J Shah, Vidhya Rao, Shashikant Nagre, Thomas M Lancaster, Sarah S Webb, Allison I Jasa, Shannon E Ronca, Freedom M Green, Hanne Andersen Elyard, JoAnn Yee, Jeffrey Klein, Larry Karnes, Frans Sollie, Todd C Zion
Journal: Vaccine
PubMed ID: 34642088
Doi: 10.1016/j.vaccine.2021.09.077
Products & Services: Endotoxin Detection & Removal System   
Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling
Authors: Hannes Merten, Fabian Brandl, Martina Zimmermann, Jonas V Schaefer, Linda Irpinio, Kine M K Sand, Jeannette Nilsen, Jan Terje Andersen, Uwe Zangemeister-Wittke, Andreas Plückthun
Journal: Eur J Pharm Biopharm
PubMed ID: 34303832
Doi: 10.1016/j.ejpb.2021.07.011
Products & Services: PCR and Cloning   
Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain
Authors: Qingbin Zhang, Mengxin Qian, Yong Wu, Yapeng Wang, Wenwen Shangguan, Jianguang Lu, Wenjie Zhao, Jun Feng
Journal: Eur J Pharmacol
PubMed ID: 33964292
Doi: 10.1016/j.ejphar.2021.174152
Products & Services: Proteins, Expression, Isolation and Analysis   
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
Authors: Ole A Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A Howard
Journal: Commun Biol
PubMed ID: 33686177
Doi: 10.1038/s42003-021-01790-2
Products & Services: Catalog Antibody   
Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention
Authors: Neville Kielau Kisalu, Lais Da Silva Pereira, Keenan J Ernste, Yevel Flores-Garcia, Azza H Idris, Mangaiarkarasi Asokan, Marlon Dillon, Scott MacDonald, Wei Shi, Xuejun Chen, Amarendra Pegu, Arne Schön, Fidel Zavala, Alejandro B Balazs, Joseph R Francica, Robert A Seder
Journal: JCI Insight
PubMed ID: 33332286
Doi: 10.1172/jci.insight.143958
Products & Services: Mutagenesis Services   
An Omalizumab Biobetter Antibody With Improved Stability and Efficacy for the Treatment of Allergic Diseases
Authors: Peipei Liu, Zhongzong Pan, Chunyin Gu, Xiaodan Cao, Xiaowu Liu, Jianjian Zhang, Zheng Xiao, Xueping Wang, Haibing Guo, Dianwen Ju, Su-Jun Deng
Journal: Front Immunol
PubMed ID: 33329588
Doi: 10.3389/fimmu.2020.596908
Products & Services: Proteins, Expression, Isolation and Analysis   
Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity
Authors: Jong Youl Lee, Taehoon Park, Eunmi Hong, Reeju Amatya, Kyung-Ah Park, Young-Hoon Park, Kyoung Ah Min, Minki Jin, Sumi Lee, Seungmi Hwang, Gu Seob Roh, Meong Cheol Shin
Journal: Biomaterials
PubMed ID: 32736262
Doi: 10.1016/j.biomaterials.2020.120250
Products & Services: Gene Synthesis   
The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals
Authors: Björn Weström, Ester Arévalo Sureda, Kateryna Pierzynowska, Stefan G Pierzynowski, Francisco-José Pérez-Cano
Journal: Front Immunol
PubMed ID: 32582216
Doi: 10.3389/fimmu.2020.01153
Products & Services: Recombinant Proteins   
Novel ACE2-IgG1 fusions with increased activity against SARS-CoV-2
Authors: Naoki Iwanaga, Laura Cooper, Lijun Rong, Brandon Beddingfield, Jackelyn Crabtree, Ralph A. Tripp,  View ORCID ProfileJay K. Kolls
Journal: biorxiv
Doi: 10.1101/2020.06.15.152157
Products & Services: Gene Synthesis   
A single-valent long-acting human CD47 antagonist enhances antibody directed phagocytic activities
Authors: Fenglan Wu, Yangsheng Qiu, Yuhong Xu
Journal: Cancer Immunol Immunother
PubMed ID: 32583154
Doi: 10.1007/s00262-020-02640-6
Products & Services: Custom Vector Construction