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Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome.

Frontiers in Physiology. 2020-01; 
Di Mauro V,Ceriotti P,Lodola F,Salvarani N,Modica J,Bang ML,Mazzanti A,Napolitano C,Priori SG,Catalucci D
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Peptide Synthesis … Loss-of-function (LoF) mutations in the CACNA1C and CACNB2 genes encoding the alpha- (Ca v α1.2) and beta2 … The coding region of SCN5A, the most common gene associated with BrS (Crotti et al., 2012) was also screened … Peptides were synthetized by GenScript (USA) … Get A Quote

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