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Reduction of Influenza A Virus Transmission in Mice by a Universal Intranasal Vaccine Candidate is Long-Lasting and Does Not Require Antibodies

J Virol. 2022-05; 
Graeme E Price, Chia-Yun Lo, Julia A Misplon, Suzanne L Epstein
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Catalog Antibody … of B/Ann Arbor/1/86 were synthesized by GenScript (Piscataway, NJ). A pool of severe acute … A/PR/8/34 (H1N1) and B/NP from B/Ann Arbor/1/86 were custom produced by GenScript. … Get A Quote

摘要

Vaccination against influenza virus infection can protect the vaccinee and also reduce transmission to contacts. Not all types of vaccines induce sterilizing immunity via neutralizing antibodies; some instead permit low-level, transient infection. There has been concern that infection-permissive influenza vaccines may allow continued spread in the community despite minimizing symptoms in the vaccinee. We have explored that issue for a universal influenza vaccine candidate that protects recipients by inducing T cell responses and nonneutralizing antibodies. Using a mouse model, we have shown previously that an adenoviral vectored vaccine expressing nucleoprotein (NP) and matrix 2 (M2) provides broad protection a... More

关键词

T cells, antibody, influenza, intranasal, mouse model, transmission, universal vaccine