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Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries

Molecules. 2021-06; 
Sakkarapalayam M Mahalingam, Karson S Putt, Madduri Srinivasarao, Philip S Low
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis … 2. Methods. 2.1. Materials. S0456 was purchased from Few Chemicals (Bitterfeld-Wolfen, Germany). 2-(1H-7-Azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate methanaminium (HATU) was obtained from Genscript Inc. (Piscataway, NJ, USA) … Get A Quote

摘要

The inadvertent severing of a ureter during surgery occurs in as many as 4.5% of colorectal surgeries. To help prevent this issue, several near-infrared (NIR) dyes have been developed to assist surgeons with identifying ureter location. However, the majority of these dyes exhibit at least some issue that precludes their widespread usage such as high levels of uptake in other tissues, overlapping emission wavelengths with other NIR dyes used for other fluorescence-guided surgeries, and/or rapid excretion times through the ureters. To overcome these limitations, we have synthesized and characterized the spectral properties and biodistribution of a new series of PEGylated UreterGlow derivatives. The most promising... More

关键词

PEG pharmacokinetics, fluorescence-guided surgery, near-infrared dye, ureter imaging