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Molecular Biology Reagents> | … 2. Methods. 2.1. Materials. α-Tetrahydropyranyloxy-ω-hydroxyl poly(ethylene glycol) (THP-PEG-OH) (M n 5, 000) was purchased from NOF Co., Ltd. (Tokyo, Japan). Boc-GPVGLIG- COOH and Boc-gpvglig-COOH were purchased from GenScript, Co., LLC. (USA) … | Get A Quote |
The enhanced permeability and retention (EPR) effect is fundamental to tumor-targeted drug delivery using nanoparticles. However, recent studies reported heterogeneity of the EPR effect, and companion diagnostics are considered to be key to predicting and optimizing the benefits of the EPR effect. Here, as a new material to simply endow the function of companion diagnostics to nanoparticles, we designed a poly(ethylene glycol) (PEG) derivative conjugated with low molecular fluorescent dye through synthetic substrate linker that can be cleaved in response to MMP-2, which is overexpressed in tumor extracellular matrix. Upon tumor accumulation, the low molecular fluorescent dye is released from the PEG and quickly... More