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Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives

J Control Release. 2020; 
Xiaohang Sun, Takahiro Nomoto, Hiroyasu Takemoto, Makoto Matsui, Haochen Guo, Yudi Sun, Yutaka Miura, Nobuhiro Nishiyama
Products/Services Used Details Operation
Molecular Biology Reagents … 2. Methods. 2.1. Materials. α-Tetrahydropyranyloxy-ω-hydroxyl poly(ethylene glycol) (THP-PEG-OH) (M n 5, 000) was purchased from NOF Co., Ltd. (Tokyo, Japan). Boc-GPVGLIG- COOH and Boc-gpvglig-COOH were purchased from GenScript, Co., LLC. (USA) … Get A Quote

摘要

The enhanced permeability and retention (EPR) effect is fundamental to tumor-targeted drug delivery using nanoparticles. However, recent studies reported heterogeneity of the EPR effect, and companion diagnostics are considered to be key to predicting and optimizing the benefits of the EPR effect. Here, as a new material to simply endow the function of companion diagnostics to nanoparticles, we designed a poly(ethylene glycol) (PEG) derivative conjugated with low molecular fluorescent dye through synthetic substrate linker that can be cleaved in response to MMP-2, which is overexpressed in tumor extracellular matrix. Upon tumor accumulation, the low molecular fluorescent dye is released from the PEG and quickly... More

关键词

Companion diagnostics, EPR effect, MMP-2, Polymer