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Inhibiting the NF-κB pathway enhances the antitumor effect of cabazitaxel by downregulating Bcl-2 in pancreatic cancer

Int J Oncol. 2020; 
Zequn Li, Zefeng Xuan, Jian Chen, Wenfeng Song, Shiyu Zhang, Cheng Jin, Mengqiao Zhou, Shusen Zheng, Penghong Song
Products/Services Used Details Operation
Molecular Biology Reagents … The BCA Protein Assay Kit (Thermo Fisher Scientific, Inc.) was used to quantify proteins in each fraction. Proteins (30 µg) were separated using SurePAGE™ gels 4‑20% (GenScript) and transferred onto polyvinylidene fluoride membranes (EMD Millipore) … Get A Quote

摘要

Optimizing the currently available treatment options for pancreatic cancer (PC) is a priority. Cabazitaxel (CTX), a semisynthetic taxane, is mainly used for treating patients with PC who are resistant to paclitaxel (PTX) or docetaxel, due its poor affinity for P‑glycoprotein. However, there are only a few studies demonstrating the effect of CTX on PC. The present study aimed to investigate the efficiency and underlying mechanism of CTX in PC treatment. Cell proliferation, colony formation assay and apoptosis analysis were achieved in the two human PC cell lines AsPC‑1 and BxPC‑3. Drug sensitivity test was performed in BxPC‑3 tumor‑bearing mice. The results demonstrated that CTX had a lower half maxi... More

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