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Host Anti-antibody Responses Following Adeno-associated Virus-mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

Mol Ther. 2015-10-01; 
José M Martinez-Navio, Sebastian P Fuchs, Sònia Pedreño-López, Eva G Rakasz, Guangping Gao, Ronald C Desrosiers
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Custom Vector Construction … Peptides were all synthesized by GenScript and specific sequences are indicated in Supplementary Figure S1. Recombinant antibodies. HEK293T cells were expanded and then transfected with recombinant AAV vector plasmids … Get A Quote

摘要

Long-term delivery of antibodies against the human immunodeficiency virus (HIV) using adeno-associated virus (AAV) vectors is a promising approach for the prevention or treatment of HIV infection. However, host antibody responses to the delivered antibody are a serious concern that could significantly limit the applicability of this approach. Here, we describe the dynamics and characteristics of the anti-antibody responses in monkeys that received either rhesus anti-simian immunodeficiency virus (SIV) antibodies (4L6 or 5L7) in prevention trials or a combination of rhesusized human anti-HIV antibodies (1NC9/8ANC195/3BNC117 or 10-1074/10E8/3BNC117) in therapy trials, all employing AAV1 delivery of IgG1. Eight ou... More

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