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The Pro12Ala polymorphism in the PPAR-γ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus

Cell Mol Biol Lett. 2019-03-01; 
Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Mina Fathi-Kazerooni, Behrooz Johari, Zohreh Saltanatpour
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Molecular Biology Reagents … PCR. The following primers (GenScript, USA) were used: Forward: 5ˊ- GCCAATTCAAGCC CAGTC- 3ˊ Reverse: 5ˊ- CGTCCCCAATAGCCGTATC- 3ˊ Genomic DNA (2.5 µl) was added to the reaction mixture (22.5 µl) to make the final reaction volume 25 µl … Get A Quote

摘要

unassigned: The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant association between Pro12Ala polymorphism of the PPAR-γ2 gene and metabolic disorders. Therefore, this study aimed to evaluate the association of Pro12Ala polymorphism with increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus. unassigned: This cross-sectional study was performed on 145 healthy control subjects and 145 NAFLD patients with a history of type 2 diabetes. Pro12Ala polymorphism genotyping was performed using PCR-restriction fragment length polymorphism (RFLP) techniq... More

关键词

NAFLD, PPAR­γ2 gene, Pro12Ala polymorphism, Type 2 diabetes mellitus