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Dual Regulation of Adipose Triglyceride Lipase by Pigment Epithelium-Derived Factor: A Novel Mechanistic Insight into Progressive Obesity.

Mol Cell Endocrinol.. 2013-07; 
Z Dai, W Qi, C Li, J Lu, Y Mao, Y Yao, L Li, T Zhang, Honghai Hong, Shuai Li, Ti Zhou, Zhonghan Yang, Xia Yang, Guoquan Gao, Weibin Cai. Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, China.
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摘要

Both elevated plasma free fatty acids (FFA) and accumulating triglyceride in adipose tissue are observed in the process of obesity and insulin resistance. This contradictory phenomenon and its underlying mechanisms have not been thoroughly elucidated. Recent studies have demonstrated that pigment epithelium-derived factor (PEDF) contributes to elevated plasma FFA and insulin resistance in obese mice via the activation of adipose triglyceride lipase (ATGL). However, we found that PEDF downregulates adipose ATGL protein expression despite of enhancing lipolysis. Plasma PEDF and FFA were increased in associated with a progressive high-fat-diet, and those outcomes were also accompanied by fat accumulation and a red... More

关键词

ATGL; PEDF; Lipolysis; Obesity; Proteasome degradation pathway; Free fatty acid