| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … Cultured splenocytes from experimental and control mice were re-stimulated in vitro with PADRE, P30, P2 (all are from GenScript, NJ), Aβ 40 (American Peptide, CA), Lu AF20513, or irrelevant peptides (10 μg/ml of each peptide). 2.6. Statistical analysis … | Get A Quote |
Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulatory patches (LT-IS) dramatically enhances the onset and magnitude of immune responses to DNA- and protein-based vaccines for Alzheimer's disease following intradermal immunization via gene gun and conventional needles, respectively. Our studies suggest that the immune activation mediated by LT-IS offers improved potency for generating AD-specific vaccination responses that should be investigated as ... More
