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miR-140-3p Suppresses Cell Growth And Induces Apoptosis In Colorectal Cancer By Targeting PD-L1.

Onco Targets Ther. 2019; 
Jiang W,, Li T,, Wang J,, Jiao R,, Shi X,, Huang X,, Ji G,.
Products/Services Used Details Operation
Molecular Biology Reagents … USA) Luciferase Reporter Assay The wild-type (WT) and mutant PD-L1-3ʹUTR (MUT) plasmids were constructed by GenScript (Nanjing, China) Cells were seeded in 24-well plates and grown for 24 hrs before transfection … Get A Quote

摘要

A variety of miRNAs have been recently reported to be abnormally expressed in colorectal cancer (CRC). A growing number of studies have demonstrated that aberrantly expressed miRNAs are closely related to the development and progression of CRC. It has been found that miR-140-3p plays a vital role in several cancers. However, its expression, roles and mechanisms in CRC are remain unknown.,Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used to determine miR-140-3p expression in CRC tissues and cell lines. CCK8, migration, invasion and flow cytometric assays were used to determine the influence of miR-140-3p upregulation on cell proliferation, migration, invasion and apoptosis of CRC c... More

关键词

PD-L1; apoptosis; colorectal cancer; microRNA-140-3p