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Cx43 in mesenchymal stem cells promotes angiogenesis of the infarcted heart independent of gap junctions.

Mol Med Rep. 2014; 
Wang DG, Zhang FX, Chen ML, Zhu HJ, Yang B, Cao KJ.
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Custom Vector Construction … CA, USA). The siRNA sequence 5′-CGT GGA GAT GCA CCT GAA GTT CAA GAG ACT TCA GGT GCA TCT CCA CG TTT TTT-3′ was cloned into the pRNA-U6-neo- vector (GenScript Co., Piscataway, NJ, USA). Plasmids were … Get A Quote

摘要

Mesenchymal stem cells (MSCs) with elevated levels of connexin 43 (Cx43) have been shown to exhibit improved protection for ischemic hearts. However, it remains unclear whether Cx43 is involved in the paracrine actions of angiogenesis, the major mechanism of cell therapy. In the present study, an in vitro model with deprivation of oxygen and a murine myocardial infarction model with permanent ligation of the left anterior‑descending (LAD) coronary artery were used to determine whether gap junctions in MSCs promote angiogenesis. It was observed that MSCs that overexpressed Cx43 (MSCs‑Cx43), improve the cardiac function of infarcted myocardium as compared with control MSCs (MSCs‑vector) and MSCs with Cx43 k... More

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