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Role of Angiotensin-(1-7) via MAS receptor in human sperm motility and acrosome reaction.

Reproduction. 2020; 
Valdivia A, Cortés L, Beitia M, Totorikaguena L, Agirregoitia N, Corcostegui B, Casis L, Matorras R,, Irazusta J, Agirregoitia E.
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Biochemicals … 108 Reagents 109 Angiotensin (1-7) [Ang-(1-7)] was purchased by Sigma Aldrich (St. Louis, MO) and its 110 antagonist A779 by Genscript (Piscataway, NJ). 111 Incubation assays 112 For incubation assays, sperm cells were separated in a unique centrifugation step (1800 … Get A Quote

摘要

Rennin-angiotensin system (RAS) has been involved in sperm function, even so, little is known about the implication of one of the RAS axis formed by Ang-(1-7) (angiotensin-(1-7)) and MAS receptor. Hence, in the present work, we focused on elucidating the function of the MAS receptor in human spermatozoa. We analyzed the expression and localization of MAS receptor in human spermatozoa and we observed if its activation is able to modulate the sperm motility of normal motility and/or asthenozoospermic patients, as well as, the acrosome reaction of the spermatozoa. MAS receptor is present in human mature spermatozoa, not only at the mRNA level but also at protein level. MAS is localized at the acrosome region, as w... More

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