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LincRNA TINCR facilitates excessive proliferation and inflammation in post-burn skin fibroblasts by directly binding with SND1 protein and inducing SND1-mediated TGF-β1 expression.

Biochem Biophys Res Commun. 2019; 
Qin G, Song Y, Guo Y, Sun Y, Zeng W.
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摘要

In this study, we found that lincRNA-TINCR was significantly upregulated in burn-injured skin tissues in vivo and heat-stimulated dermal fibroblasts in vitro, accompanied by an increase in TGF-β1 expression. TINCR overexpression promoted cell proliferation, colony formation, release of pro-inflammatory factors and expression of TGF-β1 protein in human primary fibroblasts under normal condition. Moreover, silencing TINCR reduced expression of TGF-β1, cell proliferation, colony formation and inflammation in heat-stressed fibroblasts. Subsequently, motif analysis in TINCR sequence revealed that there were two potential target sites for the RNA-binding protein Staphylococcal Nuclease and Tudor Domain Containin... More

关键词

Burn injury/heat stress; Dermal fibroblast; RNA-Protein interaction; SND1; TGF-β1; lincRNA TINCR