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Shp2 expression is upregulated in cervical cancer, and Shp2 contributes to cell growth and migration and reduces sensitivity to cisplatin in cervical cancer cells.

Pathol Res Pract. 2019;

Cao M, Gao D, Zhang N, Duan Y, Wang Y, Mujtaba H, Wang Y.

Products/Services Used	Details	Operation
Gene Synthesis	The primers were synthesized by GenScript Biotech (China) with the following sequences: β-actin F: 5′-CATCATGAAGTGTGACG TGG-3′, β-actin R: 5′-GATCCACACGGAGTACTTGC-3′; and Shp2 F: 5′-GACTTTTGGCGGATGGTGTTCC-3′, Shp2 R: 5′-CGGCGCTTTCTTTG ACGTTCCT-3′ [13].	Get A Quote

摘要

Src homology phosphotyrosine phosphatase 2 (Shp2) has been found to be overexpressed in cervical cancer tissues. However, the influence of Shp2 on the biological behavior and sensitivity to cisplatin of cervical cancer cells remains unclear. We aimed to assess Shp2 expression in cervical tissues and cell lines and to detect the influence of Shp2 knockdown and overexpression on the biological behavior and sensitivity to cisplatin in cervical cancer cells. We found that Shp2 expression was significantly upregulated in cervical cancer tissues and cell lines, and Shp2 overexpression was associated with lymph node metastasis and a high human papillomavirus (HPV) DNA load. Shp2 knockdown inhibited cell growth and mig... More