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Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells.

Cancer Res Treat. 2019;

XuYing-Ying，YuHai-Ru，SunJia-Yi，ZhaoZhao，LiShuang，ZhangXin-Feng，LiaoZhi-Xuan，CuiMing-Ke，LiJuan，LiChan，ZhangQ

Products/Services Used	Details	Operation
Molecular Biology Reagents	To overexpress the exogenous PITX2, MCF7 cells were transfected with pPM-His-PITX2 or pPM-His vector (GenScript, Nanjing, China) using Lipofectamine 3000 (Thermo Fisher Scientific), followed by Neomycin selection (200 μg/mL, Invitrogen, Carlsbad, CA) according to the manufacturer’s instructions.	Get A Quote

摘要

Although the interferon α (IFNα) signaling and the paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in the progression of breast cancer (BCa)， it remains obscure whether these two pathways act in a coordinated manner. We therefore aimed to elucidate the expression and function of PITX2 during the pathogenesis of endocrine resistance in BCa.