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Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer.

Prostate. 2012; 
Chiriva-Internati Maurizio,Yu Yuefei,Mirandola Leonardo,D'Cunha Nicholas,Hardwicke Fred,Cannon Martin J,Cobos Everardo,Kast W Ma
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Proteins, Expression, Isolation and Analysis AKAP-4 protein was endo- toxin-free, as confirmed by endotoxin detection assay performed through ToxinSensorTM Chromogenic LAL Endotoxin Assay Kit (GenScript USA, Inc. Get A Quote

摘要

Prostate cancer (PC) is the second most common cancer in older men, after skin cancer. PC is difficult to diagnose because the prostate-specific antigen screening method is associated with many false positives. In addition there is a need to develop new and more effective treatments. Among presently available new treatments, immunotherapy is a promising approach. We investigated the expression of the cancer/testis antigen, AKAP-4, in PC patients to evaluate the possibility of exploiting AKAP-4 as a target for immunotherapy.

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