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Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).

Malar. J.. 2018;

BittencourtNajara C，LeiteJuliana A，SilvaAna Beatriz I E，PimentaTamirys S，Silva-FilhoJoão Luiz，CassianoGustavo C，LopesStefanie C P，Dos-SantosJoao C K，BourgardCatarina，NakayaHelder I，da Silva VenturaAna Maria Revorêdo，LacerdaMarcus V G，FerreiraMarcelo U，MachadoRicardo L D，AlbrechtLetusa，CostaFabio

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摘要

The genetic diversity of malaria antigens often results in allele variant-specific immunity， imposing a great challenge to vaccine development. Rhoptry Neck Protein 2 (PvRON2) is a blood-stage antigen that plays a key role during the erythrocyte invasion of Plasmodium vivax. This study investigates the genetic diversity of PvRON2 and the naturally acquired immune response to P. vivax isolates.