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Deficiency of Epithelial-Mesenchymal Transition Causes Child Indirect Inguinal Hernia.

J. Pediatr. Surg.. 2019; 
SomuncuSalih,Somuncu?zge Sezin,Ball?caBa?ak,TabandehB
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Gene Synthesis Primer sequences of target genes were designed by our group through GenScript [15] and are given in Table 1. Get A Quote

摘要

Epithelial-mesenchymal transition (EMT) describes rapid changes in cellular phenotype. During EMT, epithelial cells down-modulate cell-cell adhesion, alter polarity, reorganize cytoskeleton, become isolated, motile, and resistant to anoikis. Epithelial breakdown and epithelial cell migration are the key processes involved in the obliteration of processus vaginalis. The great majority of abnormalities are because of nonobliteration or incomplete fusion of PV. We aimed to analyze the quantitative changes of epithelial genes in adult/child patients and their controls to examine differences of the genesis of these hernias. We also aimed to investigate the potential epigenetic causes of indirect inguinal... More

关键词

EMT,Epigenetics,Epithelial–mesenchymal transition,Indirect inguinal he