Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds， 1-6， together with five known compounds， 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds， and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.
Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds， 1-6， together with five known compounds， 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds， and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.
