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High-Sensitivity Assays for Plasmodium falciparum Infection by Immuno-Polymerase Chain Reaction Detection of PfIDEh and PfLDH Antigens.

J. Infect. Dis.. 2017; 
Mu Jianbing,Andersen John F,Valenzuela Jesus G,Wellems Thom
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摘要

Rapid diagnostic tests based on Plasmodium falciparum histidine-rich protein II (PfHRP-II) and P. falciparum lactate dehydrogenase (PfLDH) antigens are widely deployed for detection of P. falciparum infection; however, these tests often miss cases of low-level parasitemia, and PfHRP-II tests can give false-negative results when P. falciparum strains do not express this antigen.

关键词

PfHRP-II,enzyme-linked immunosorbent assay,immuno-PCR,insulin-degrading enzyme,lactate dehydrogenase en