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Evidence for the in vivo safety of insulated foamy viral vectors.

Gene Ther.. 2017; 
Browning D L,Everson E M,Leap D J,Hocum J D,Wang H,Stamatoyannopoulos G,Trobridge
Products/Services Used Details Operation
Custom Vector Construction FVSGW-A1 and FVSGW -A2. Insulators were synthesized by GenScript (Piscataway, NJ). Vector production Get A Quote

摘要

Retroviral vector-mediated stem cell gene therapy is a promising approach for the treatment of hematopoietic disorders. However, genotoxic side effects from integrated vector proviruses are a significant concern for the use of retroviral vectors in the clinic. Insulated foamy viral (FV) vectors are potentially safer retroviral vectors for hematopoietic stem cell gene therapy. We evaluated two newly identified human insulators, A1 and A2, for use in FV vectors. These insulators had moderate insulating capacity and higher titers than previously developed insulated FV vectors. The A1-insulated FV vector was chosen for comparison with the previously described 650cHS4-insulated FV vector in human cord blood CD... More

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