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An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons.

eNeuro. 2017; 
Jin Dao-Zhong,Mao Li-Min,Wang Jo
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摘要

Fyn is a member of the Src family of nonreceptor tyrosine kinases and is broadly expressed in the CNS. As a synapse-enriched kinase, Fyn interacts with and phosphorylates local substrates to regulate synaptic transmission and plasticity, although our knowledge of specific targets of Fyn at synaptic sites remains incomplete and the accurate role of Fyn in regulating synaptic proteins is poorly understood. In this study, we initiated an effort to explore the interaction of Fyn with a metabotropic glutamate receptor (mGluR). We found that recombinant Fyn directly binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a . Similarly, endogenous Fyn interacts with ... More

关键词

Src,cerebellum,mGluR,phosphoryla