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Probing function and structure of trehalose-6-phosphate phosphatases from pathogenic organisms suggests distinct molecular groupings.

FASEB J.. 2017; 
Cross Megan,Lepage Romain,Rajan Siji,Biberacher Sonja,Young Neil D,Kim Bo-Na,Coster Mark J,Gasser Robin B,Kim Jeong-Sun,Hofmann And
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Custom Vector Construction : XM_001893174.1) was obtained from GenScript (Piscataway, NJ, USA) ligated into the vector p11 (obtained Get A Quote

摘要

The trehalose biosynthetic pathway is of great interest for the development of novel therapeutics because trehalose is an essential disaccharide in many pathogens but is neither required nor synthesized in mammalian hosts. As such, trehalose-6-phosphate phosphatase (TPP), a key enzyme in trehalose biosynthesis, is likely an attractive target for novel chemotherapeutics. Based on a survey of genomes from a panel of parasitic nematodes and bacterial organisms and by way of a structure-based amino acid sequence alignment, we derive the topological structure of monoenzyme TPPs and classify them into 3 groups. Comparison of the functional roles of amino acid residues located in the active site for TPPs belon... More

关键词

drug targets,enzyme inhibitors,molecular mecha