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Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.

Pharm Biol. 2017;

Nasri Imen，Chawech Rachid，Girardi Cynthia，Mas Emmanuel，Ferrand Audrey，Vergnolle Nathalie，Fabre Nicolas，Mezghani-Jarraya Raoudha，Racaud-Sultan Cl

Products/Services Used	Details	Operation
Peptide Synthesis	peptide (PAR2 AP, Genscript, Piscataway, NJ) or its inversed control (Ezbiolab Inc., Carmel, IN) for 1 h	Get A Quote

摘要

Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic， anti-inflammatory or anticancer agent. In these pathologies， the glycogen synthase kinase 3 β (GSK3β) is overactivated and represents an interesting therapeutic target. Several flavonoids can inhibit GSK3β and the purpose of this study was to search for the compounds in Diplotaxis harra which are able to modulate GSK3β.