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ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.

Cell. Mol. Immunol.. 2019-03; 
DongXiwen,ZhengZhaohui,LinPeng,FuXianghui,LiFanni,JiangJianli,Zhu
Products/Services Used Details Operation
Molecular Biology Reagents The content of ACPA IgG was verified by SPR. The control IgG was pooled from healthy individuals’ serum using similar methods. Endotoxin was removed with a Toxin EraserTM endotoxin removal kit (GenScript, NJ, USA) Get A Quote

摘要

Anti-citrullinated protein antibodies (ACPAs) are a group of autoantibodies targeted against citrullinated proteins/peptides and are informative rheumatoid arthritis (RA) biomarkers. ACPAs also play a crucial role in RA pathogenesis, and their underlying mechanism merits investigation.

关键词

Anti-citrullinated protein antibodies,CD147,IL-1β,NLRP3 inflammasome,Rheumatoid arthr