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A critical role for miR-184 in the fate determination of oligodendrocytes.

Stem Cell Res Ther. 2019-03;

AfrangNegin，TavakoliRezvan，TasharrofiNooshin，AlianAmir，Naderi SohiAlireza，KabiriMahboubeh，Fathi-RoudsariMehrnoosh，SoufizomorrodMina，RajaeiFarzad，SoleimaniMasoud，KouhkanFat

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Custom Vector Construction	… as controls in all experiments. Different scrambled sequences of miR-184 were designed using “GenScript” and “InvivoGene” websites and cloned into the pLenti-III vector in shRNA formats. Scrambled sequences are (I) GGAAGTGCAAGCGTGTGAAAGT …	Get A Quote

摘要

New insights on cellular and molecular aspects of both oligodendrocyte (OL) differentiation and myelin synthesis pathways are potential avenues for developing a cell-based therapy for demyelinating disorders comprising multiple sclerosis. MicroRNAs (miRNA) have broad implications in all aspects of cell biology including OL differentiation. MiR-184 has been identified as one of the most highly enriched miRNAs in oligodendrocyte progenitor cells (OPCs). However， the exact molecular mechanism of miR-184 in OL differentiation is yet to be elucidated.