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Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways.

Cell Commun Signal. 2019-06;

YangHuahong，LvHongming，LiHaijun，CiXinxin，PengLi

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Molecular Biology Reagents	… The horseradish peroxidase- (HRP-) conjugated anti-rabbit or anti-mouse IgG were obtained from Proteintech (Boston, MA, USA). ToxinSensor Chromogenic LAL Endotoxin Assay Kit was purchased from GenScript (Nanjing, China) …	Get A Quote

摘要

Oxidative stress and the resulting inflammation are essential pathological processes in acute lung injury (ALI). Nuclear factor erythroid 2-related factor 2 (Nrf2)， a vital transcriptional factor， possesses antioxidative potential and has become a primary target to treat many diseases. Oridonin (Ori)， isolated from the plant Rabdosia Rrubescens， is a natural substance that possesses antioxidative and anti-inflammatory effects. Our aim was to study whether the anti-inflammatory and antioxidant effects of Ori on LPS-induced ALI were mediated by Nrf2.