至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways.

Cell Commun Signal. 2019-06; 
YangHuahong,LvHongming,LiHaijun,CiXinxin,PengLi
Products/Services Used Details Operation
Molecular Biology Reagents … The horseradish peroxidase- (HRP-) conjugated anti-rabbit or anti-mouse IgG were obtained from Proteintech (Boston, MA, USA). ToxinSensor Chromogenic LAL Endotoxin Assay Kit was purchased from GenScript (Nanjing, China) … Get A Quote

摘要

Oxidative stress and the resulting inflammation are essential pathological processes in acute lung injury (ALI). Nuclear factor erythroid 2-related factor 2 (Nrf2), a vital transcriptional factor, possesses antioxidative potential and has become a primary target to treat many diseases. Oridonin (Ori), isolated from the plant Rabdosia Rrubescens, is a natural substance that possesses antioxidative and anti-inflammatory effects. Our aim was to study whether the anti-inflammatory and antioxidant effects of Ori on LPS-induced ALI were mediated by Nrf2.

关键词

Acute lung injury,Akt/Nrf2,Inflammation,MAPK/Nrf2,NF-κB,NOD-like receptor protein 3,Oridonin,Oxidative st