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Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5).

Front Physiol. 2016; 
GeorgievaElka R,BorbatPeter P,GrushinKirill,Stoilova-McPhieSvetla,KulkarniNichita J,LiangZhichun,FreedJa
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Peptide Synthesis Wild type (wt) and G34A mutant of M2TMD21−49 peptides (with the sequences DSSDPLVVAASIIG[A]ILHLILWILDRCFFK, L46C), synthesized commercially (GenScript Inc., USA) to the purity higher than 98%, were received as powders. Get A Quote

摘要

Department of Chemistry and Chemical Biology, Cornell UniversityIthaca, NY, USA; National Biomedical Center for Advanced ESR TechnologyIthaca, NY, USA.,Department of Chemistry and Chemical Biology, Cornell UniversityIthaca, NY, USA; National Biomedical Center for Advanced ESR TechnologyIthaca, NY, USA.,Department of Neuroscience and Cell Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston Galveston, TX, USA.,Department of Neuroscience and Cell Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston Galveston, TX, USA.,College of Art and Sci... More

关键词

DEER spectroscopy,ESR,amantadine,influenza M2 proton channel,protein-drug interactions,protein-membrane interactions,proton channel inhibi