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An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity.

Nanoscale. 2011;

XiaXiaohu，YangMiaoxin，OetjenL Kyle，ZhangYu，LiQingge，ChenJingyi，XiaYo

Products/Services Used	Details	Operation
Peptide Synthesis	… To fabricate the MMP-responsive probe, we conjugated a FITC-labeled C-terminus peptide (FITC–GKGPLGVRGC–NH 2 , GenScript, NJ) to the surfaces of Au nanocages (with an LSPR peak at 770 nm) through the free thiol group on the side chain of cysteine …	Get A Quote

摘要

A gold nanocage and dye conjugate has been demonstrated for use with photoacoustic imaging and fluorescence detection of protease activity. The detection sensitivity could be maximized by using gold nanocages with a localized surface plasmon resonance peak away from the emission peak of the dye. These hybrids can be potentially used as multimodal contrast agents for molecular imaging.